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• W2290907024 abstract "Objective: To evaluate the potential of Azadirachta indica leaf extracts against Salmonella typhimurium- induced inflammation in BalB/c mice. Design: Qualitative tests of A. indica leaf extracts were con - ducted for screening of various phytochemicals. The anti- inflammatory potential of leaf extracts on S. typh- imurium and its outermembrane proteins (OMPs)-induced inflammation was assessed by hyperalgesic (flicking) re - sponse of the mice inflammed paws. The monokines (Il-1 a, Il-6 and TNF-a) activities in the culture supernatants of mac - rophages (infected with bacteria and interacted with OMPs) in the presence or absence of A. indica leaf extracts was assessed by ElISa. Results: aqueous and petroleum ether A. indica leaf extracts reduced the inflammation caused by S. typhimurium and its OMPs as assessed by paw flicking response. Petroleum ether A. indica leaf extract was found to be more effective than aqueous A. indica leaf extract. Significantly lower levels of monokines (Il-6 and TNF-a) were also observed in the pres - ence of petroleum ether A. indica leaf extracts than aqueous A. indica leaf extract. These observations may be due to the presence of steroids and triterpenoids observed in petroleum ether extract. Conclusion: Petroleum ether A. indica leaf extract seems promising to combat S. typhimurium-induced inflammation." @default.
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• W2290907024 date "2009-01-01" @default.
• W2290907024 modified "2023-09-23" @default.
• W2290907024 title "Research Article Potential of Azadirachta indica against Salmonella typhimurium- induced inflammation in bAlb/c mice" @default.
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