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- W2290974768 abstract "LESS INTENSIVE THERAPY FOR OLDER AML PATIENTS. W. Thomas Clarke, Peter W. Marks, and Nikolai A. Podoltsev. Section of Hematology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT. Specific aims: This single-‐center, retrospective study compared overall survival and hospitalization in older patients with acute myeloid leukemia (AML) receiving first-‐line treatment with standard induction chemotherapy and decitabine therapy. Methods: Between January 2000 and December 2009, 36 patients at Yale-‐New Haven Hospital age 65 years and older with newly diagnosed AML received standard induction chemotherapy (n=11), decitabine therapy (n=11), or supportive care only (n=14). Data obtained included baseline characteristics, achievement of remission, overall survival, inpatient and outpatient visits, and early death. Results: When compared to standard induction chemotherapy, decitabine patients were significantly older (77 vs 69 years, P = .020) yet had a favorable but nonsignificant trend for increased overall survival (9 vs 7 months, P = .192) and spent significantly fewer days in the hospital (30 vs 41 days, P = .047). Supportive care patients were older (84.5 years) and had a median survival of only 0.6 months. Conclusions: Compared to standard induction chemotherapy, decitabine as first-‐ line therapy for AML in older patients reduced hospitalization and had a similar overall survival." @default.
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- W2290974768 date "2013-01-01" @default.
- W2290974768 modified "2023-09-23" @default.
- W2290974768 title "Less Intensive Therapy For Older Aml Patients" @default.
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