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- W2291003829 abstract "A straightforward nanoprecipitating method was developed to prepare water dispersible curcumin (CCM)-loaded nanoscale zeolitic imidazolate framework-8 (CCM@NZIF-8) nanoparticles (NPs). The as-synthesized CCM@NZIF-8 NPs possess high drug encapsulation efficiency (88.2%), good chemical stability and fast drug release in tumor acidic microenvironments. Confocal laser scanning microscopy and cytotoxicity experiments reveal that NZIF-8 based nanocarriers promote the cellular uptake of CCM and result in higher cytotoxicity of CCM@NZIF-8 than that of free CCM toward HeLa cells. The in vivo anticancer experiments indicate that CCM@NZIF-8 NPs exhibit much higher antitumor efficacy than free CCM. This work highlights the potential of using nanoscale metal organic framworks (NMOFs) as a simple and stable platform for developing a highly efficient drug delivery system in cancer treatment." @default.
- W2291003829 created "2016-06-24" @default.
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- W2291003829 creator A5043772840 @default.
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- W2291003829 date "2015-09-30" @default.
- W2291003829 modified "2023-10-18" @default.
- W2291003829 title "One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer" @default.
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- W2291003829 doi "https://doi.org/10.1021/acsami.5b04315" @default.
- W2291003829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26403308" @default.
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