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- W2291023975 abstract "Studies have shown positive effect mainly in weight gain inpa- tients with amyotrophic lateral sclerosis (ALS) supplemented with branched chain amino acids (BCAA). However, recent studies have shown that excessive and chronic intake has contributed to the worse ning of the disease progression, probably because the amino acids are glutamate precursors. The objective of this study was to assess the evidence about the use of BCAA by patients with ALS, with the aim to clarify pertinent issues for its intake. A search was conducted in data bases for scientific papers related to the intake of BCAA in ALS, between 1988 and 2013. For these review six articles re - lated to the use of BCAA in ALS were found. Of these, one described strength improvement, while the remaining reported weight gain or no significant effects in relation to the outcome. Additionally, it was possible to observe a close relationship between the excessive and chronic BCAA intake with the worsening of the disease. Considering the presente day available knowledge BCAA supplementation should not be indicated due to the possible harmful effect. The intake of ap - propriated protein foods should be consumed by these patients, re- specting the suggested recommendation. However, more studies are necessary due to the scarce papers in this area." @default.
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- W2291023975 date "2014-01-01" @default.
- W2291023975 modified "2023-09-26" @default.
- W2291023975 title "Consumo de aminoácido de cadeia ramificada na esclerose lateral amiotrófica: suplemento proteico ou substância neurotóxica? Branched-chain amino acid consumption in amyotrophic lateral sclerosis: protein supplement or neurotoxic substance?" @default.
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