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- W2291136701 abstract "Eleven patients with hairy cell leukemia (HCU were treated with YK-176 (2′-deoxycoformycin) at a dose of 5 mg/m2 by intravenous injection every week or every other week. Patients received a median of eight (range 4–19) injections of YK-176. Five patients had previously been untreated, four of whom had massive splenomegaly. Six patients had previously been treated, four with interferon-α (IFN-α) or IFN-α and chemotherapy and two with prednisolone. Two patients had had splenectomies. Five patients achieved complete remission (CR) and six, partial remission (PR) according to WHO criteria (remission rate 100%, 95% confidence interval (Cl) 74–100%). All six neutropenic patients recovered >1,500/μl neutrophils, six of seven anemic patients recovered >12.0 g/dl hemoglobin and five of nine thrombocytopenic patients recovered >100,000/μl platelets following the treatment. According to the response criteria for HLC, five patients achieved CR, two PR and four minor response. The overall remission (CR + PR) rate was 64% (95% Cl 35–85%). The CR and PR have lasted from >30 to >718 days (median, >281 days) so far with no relapses. Of four patients previously treated with IFN-α, two achieved CR and one, PR. All patients were alive with a median survival time of >290 days from treatment (range >50–>763 days). The treatment was generally well tolerated. Mild to moderate nausea, vomiting, appetite loss and general fatigue were experienced in two patients, skin rash in one and a transient fever in three. YK-176 was a highly active agent in the treatment of HCL." @default.
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- W2291136701 date "1992-12-01" @default.
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- W2291136701 title "Treatment of Hairy Cell Leukemia with Deoxycoformycin (YK-176)" @default.
- W2291136701 doi "https://doi.org/10.1093/oxfordjournals.jjco.a039587" @default.
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