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- W2291211086 abstract "Pelvic lymph node dissection (PLND) remains the best means for detecting lymph node metastasis (LNM) in prostate cancer (PCa). PLND yields valuable staging information thatmay help to guide future therapies and provides durable long-term cancer control in nearly 30% of men found to have LNM after radical prostatectomy [1]. The staging accuracy of PLND depends on the extent of the anatomical template used; the higher the number of lymph nodes retrieved, the greater is the likelihood of detecting metastatic nodes [2]. This finding represents a convincing argument for utilizing an extended anatomical template for PLND, particularly since the indications for radical prostatectomy have shifted from low-risk disease and increasingly include patients with high-risk PCa, who are likely to present with LNM. However, extended PLND is not fully adopted by all surgeons [3]. Possible reasons for underutilization of extended PLND include the potential risk of greater morbidity, the longer operating time [4], and the fact that the extended template may not encompass all the lymphatic drainage sites. In a study by Mattei et al [5], up to 35% of prostate lymphatic drainage sites remained outside the extended anatomical template, which includes the external iliac, hypogastric, and obturator fossa nodal packets. To circumvent these limitations, several investigators have explored the possibility of dissection based on a sentinel lymph node. These investigations include injection of radiotracers such as colloid-bound Tc directly into the prostate to detect the lymphatic drainage of the prostate preoperatively on single-photon emission computed" @default.
- W2291211086 created "2016-06-24" @default.
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- W2291211086 date "2016-11-01" @default.
- W2291211086 modified "2023-09-25" @default.
- W2291211086 title "The Sentinel Lymph Node Concept and Novel Approaches in Detecting Lymph Node Metastasis in Prostate Cancer" @default.
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- W2291211086 doi "https://doi.org/10.1016/j.eururo.2016.02.047" @default.
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