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- W2291218964 abstract "Intracoronary near-infrared spectroscopy (NIRS) can identify lipid in the coronary arteries, but lacks depth resolution. Anovel catheter is currently in clinical use that combines NIRS with intravascular ultrasound (IVUS), which providesdepth-resolved structural information via the IVUS modality. A measure designated as lipid-rich plaque burden (LRPB)has been proposed as a means to interpret the combined acoustic and optical information of NIRS-IVUS. LRPB isdefined as the area created by the intersection of the NIRS lipid-rich arc with the corresponding IVUS-measured plaqueburden. We determined the correlation in human coronary autopsy specimens between LRPB, a measure of lipidpresence and extent available via intravascular imaging in patients, and the area of lipid-rich plaque as determined by thegold-standard of histology.Fifteen artery segments from 8 human autopsy hearts were imaged with the NIRS-IVUS system (TVC Imaging System,Infraredx Inc., Burlington, MA). Arteries were imaged in a specialty fixture that assured accurate co-registrationbetween imaging and histology. The arteries were then fixed and divided into 2 mm blocks for histological staining.Pathological contouring of lipid-rich areas was performed on the stained thin sections for 54 lipid-rich blocks.Computation of LRPB was performed on transverse NIRS-IVUS frames corresponding to the histologic sections. Thequantified LRPB was frequently higher than the lipid-rich plaque area determined by histology, because the regiondenoted by the EEL and lumen within the NIRS lipid-rich arc is not entirely comprised of lipid. Overall, a moderate tostrong correlation (R = 0.73) was found between LRPB determined by NIRS-IVUS imaging and the lipid-rich plaquearea determined by histology. LRPB, which can be measured in patients with NIRS-IVUS imaging, corresponds to theamount of lipid-rich plaque in a coronary artery. LRPB should be evaluated in prospective clinical trials for its ability toidentify vulnerable plaques." @default.
- W2291218964 created "2016-06-24" @default.
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- W2291218964 date "2016-02-29" @default.
- W2291218964 modified "2023-10-03" @default.
- W2291218964 title "Evaluation of combined near-IR spectroscopic (NIRS)-IVUS imaging as a means to detect lipid-rich plaque burden in human coronary autopsy specimens" @default.
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- W2291218964 doi "https://doi.org/10.1117/12.2209701" @default.
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