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- W2291244103 abstract "microRNAs regulate gene expression at the post-transcription level and are implicated in many aspects of cellular physiology. Our previous study shows that microRNA-29b (miR-29b) acts as a biological repressor of intestinal mucosal growth, but its exact down-stream targets remain largely unknown. This study tested the hypothesis that miR-29b inhibits intestinal mucosal growth by altering Wnt-signaling activity through modulation of Wnt co-receptor LRP6 (LDL receptor-related protein 6) expression. Methods: Studies were conducted in Caco-2 cells, and miR-29b function was examined by its ectopic overexpression and silencing. Results: The LRP6 mRNA was a novel target of miR-29b since it directly bound to the miR-29b as measured by biotinylated RNA pull-down assays. Increased [miR-29b/LRP6 mRNA] association by transfection with the miR-29b precursor decreased the rate of newly LRP6 protein synthesis but did not affect the stability of LRP6 mRNA as shown by its half-life, whereas miR-29b silencing by transfection with the antagomir targeting miR-29b increased LRP6 translation. LRP6 translation was also inhibited by miR-29b through a process involving RNA-binding protein HuR (a potent enhancer of LRP6 translation), since miR-29b also interacted with and repressed HuR mRNA translation. Conclusions These data indicate that miR-29b inactivates Wnt-signaling by inhibiting LRP6 translation, thus down-regulating intestinal epithelial renewal." @default.
- W2291244103 created "2016-06-24" @default.
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- W2291244103 date "2015-04-01" @default.
- W2291244103 modified "2023-10-16" @default.
- W2291244103 title "miR‐29b Regulates Intestinal Epithelium Homeostasis by Modulating Wnt Co‐receptor LRP6 Translation" @default.
- W2291244103 doi "https://doi.org/10.1096/fasebj.29.1_supplement.851.1" @default.
- W2291244103 hasPublicationYear "2015" @default.
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