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- W2291337141 endingPage "185" @default.
- W2291337141 startingPage "174" @default.
- W2291337141 abstract "Ion channels are integral membrane proteins that allow passive diffusion of ions across membranes. In neurons and in other excitable cells, the harmonious coordination between the numerous types of ion channels shape and propagate electrical signals. Increased accumulation of reactive oxidative species (ROS), and subsequent oxidation of proteins, including ion channels, is a hallmark feature of aging and may contribute to cell failure as a result. In this review we discuss the effects of ROS on three major types of ion channels of the central nervous system, namely the potassium (K+), calcium (Ca2+) and sodium (Na+) channels. We examine two general mechanisms through which ROS affect ion channels: via direct oxidation of specific residues and via indirect interference of pathways that regulate the channels. The overall status of the present studies indicates that the interaction of ion channels with ROS is multimodal and pervasive in the central nervous system and likely constitutes a general mechanism of aging susceptibility." @default.
- W2291337141 created "2016-06-24" @default.
- W2291337141 creator A5015352772 @default.
- W2291337141 creator A5072924796 @default.
- W2291337141 date "2016-05-01" @default.
- W2291337141 modified "2023-09-27" @default.
- W2291337141 title "Oxidation of ion channels in the aging nervous system" @default.
- W2291337141 cites W1445716912 @default.
- W2291337141 cites W1485183426 @default.
- W2291337141 cites W1489396516 @default.
- W2291337141 cites W1492457747 @default.
- W2291337141 cites W1497537668 @default.
- W2291337141 cites W1504073232 @default.
- W2291337141 cites W1524359813 @default.
- W2291337141 cites W1529262908 @default.
- W2291337141 cites W1599277155 @default.
- W2291337141 cites W1620179564 @default.
- W2291337141 cites W1667367966 @default.
- W2291337141 cites W1820758986 @default.
- W2291337141 cites W1839459538 @default.
- W2291337141 cites W1942590357 @default.
- W2291337141 cites W1960357398 @default.
- W2291337141 cites W1966287435 @default.
- W2291337141 cites W1967127459 @default.
- W2291337141 cites W1971319948 @default.
- W2291337141 cites W1971576287 @default.
- W2291337141 cites W1972268121 @default.
- W2291337141 cites W1977983510 @default.
- W2291337141 cites W1979504930 @default.
- W2291337141 cites W1980007713 @default.
- W2291337141 cites W1982527850 @default.
- W2291337141 cites W1982647833 @default.
- W2291337141 cites W1982715379 @default.
- W2291337141 cites W1983177874 @default.
- W2291337141 cites W1984041863 @default.
- W2291337141 cites W1986589519 @default.
- W2291337141 cites W1988664434 @default.
- W2291337141 cites W1990360300 @default.
- W2291337141 cites W1990653561 @default.
- W2291337141 cites W1993938009 @default.
- W2291337141 cites W1994493541 @default.
- W2291337141 cites W1995589371 @default.
- W2291337141 cites W1996181447 @default.
- W2291337141 cites W1997135806 @default.
- W2291337141 cites W1997960386 @default.
- W2291337141 cites W1999936371 @default.
- W2291337141 cites W2000072607 @default.
- W2291337141 cites W2001386863 @default.
- W2291337141 cites W2006099430 @default.
- W2291337141 cites W2007211412 @default.
- W2291337141 cites W2009697737 @default.
- W2291337141 cites W2009902566 @default.
- W2291337141 cites W2011385800 @default.
- W2291337141 cites W2011629581 @default.
- W2291337141 cites W2013351785 @default.
- W2291337141 cites W2017917068 @default.
- W2291337141 cites W2018995978 @default.
- W2291337141 cites W2021159562 @default.
- W2291337141 cites W2023078600 @default.
- W2291337141 cites W2023904007 @default.
- W2291337141 cites W2024208476 @default.
- W2291337141 cites W2025801062 @default.
- W2291337141 cites W2028028255 @default.
- W2291337141 cites W2029568046 @default.
- W2291337141 cites W2031231661 @default.
- W2291337141 cites W2032327611 @default.
- W2291337141 cites W2032455525 @default.
- W2291337141 cites W2033265046 @default.
- W2291337141 cites W2034068474 @default.
- W2291337141 cites W2035670175 @default.
- W2291337141 cites W2035677599 @default.
- W2291337141 cites W2036272059 @default.
- W2291337141 cites W2037775358 @default.
- W2291337141 cites W2038787225 @default.
- W2291337141 cites W2039213813 @default.
- W2291337141 cites W2039512686 @default.
- W2291337141 cites W2039547987 @default.
- W2291337141 cites W2040373875 @default.
- W2291337141 cites W2041402562 @default.
- W2291337141 cites W2042901476 @default.
- W2291337141 cites W2046823409 @default.
- W2291337141 cites W2048877266 @default.
- W2291337141 cites W2049187218 @default.
- W2291337141 cites W2049511526 @default.
- W2291337141 cites W2050066016 @default.
- W2291337141 cites W2050196115 @default.
- W2291337141 cites W2051709136 @default.
- W2291337141 cites W2056177677 @default.
- W2291337141 cites W2056666484 @default.
- W2291337141 cites W2060860837 @default.
- W2291337141 cites W2064534455 @default.
- W2291337141 cites W2069446582 @default.
- W2291337141 cites W2071140186 @default.
- W2291337141 cites W2073602735 @default.
- W2291337141 cites W2075354580 @default.
- W2291337141 cites W2076868543 @default.
- W2291337141 cites W2078117880 @default.
- W2291337141 cites W2078684933 @default.