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- W229135024 abstract "A 44-year-old female with malignant astrocytoma received subtotal removal and high dose (200 mg/m2) intra-arterial 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2- chloroethyl)-3-nitrosourea hydrochloride (ACNU) with autologous bone marrow transplantation. Tumor remission with minimal bone marrow suppression was achieved. However, she developed severe encephalopathy and computed tomographic scans revealed a low-density area at the ACNU delivery site. She received glycerol solution to treat the brain edema and recovered completely from the encephalopathy. Intra-arterial ACNU exceeding 200 mg/m2 possibly causes neurotoxicity." @default.
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- W229135024 date "1991-01-01" @default.
- W229135024 modified "2023-10-16" @default.
- W229135024 title "Treatment of Malignant Glioma with High Dose Intra-arterial ACNU and Autologous Bone Marrow Transplantation" @default.
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- W229135024 doi "https://doi.org/10.2176/nmc.31.654" @default.
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