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- W2291373435 abstract "Purpose. This study aimed to investigate the role of carbohydrate antigen 19-9 (CA19-9) in rectal cancer patients with normal carcinoembryonic antigen (CEA). Patients and Methods. From Jan 2001 to Dec 2010, 135 Patients who underwent preoperative chemoradiotherapy (CRT) followed by radical surgical resection were retrospectively enrolled from a prospectively constructed database. Characteristics of patients according to pre-CRT andpost-CRT CA19-9 concentrations were analyzed. Results. Patients with high post-CRT CA19-9 (≥ 37.0 u/ml) level were likely to have higher lymph node metastasis rate and tumor recurrence rate than those with normal post-CRT CA19-9 (＜ 37.0 ng/ml) level. Univariate and multivariate analysis showed that post-CRT CA19-9 level (HR = 8.474, 95% CI = 1.006~71.403) and ypN stage (HR = 2.422, 95% CI = 1.098~5.346) were independent prognostic factors for disease free survival rate.We also found that patients with high levels of post-CRT CA19-9 had a higher risk of lung metastasis (50.0% vs. 14.4%, p = 0.013). Conclusions. Post-CRT CA19-9 level might be an independent prognostic factor for disease-free survival in rectal cancer patients with normal (＜ 5 ng/ml) pre-CRT CEA treated with preoperative CRT and radical surgery. An aggressive surveillance protocol for lung metastasis should be used for those patients with high post-CRT CA19-9 levels." @default.
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- W2291373435 date "2014-09-01" @default.
- W2291373435 modified "2023-10-18" @default.
- W2291373435 title "Clinical Relevance of Cabohydrate Antigen 19-9 Level after Chemoradiotherapy in Rectal Cancer Patients with Normal Carcinoembryonic Antigen Level" @default.
- W2291373435 doi "https://doi.org/10.6312/scrstw.2014.25(3).10322" @default.
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