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• W2291405727 endingPage "116" @default.
• W2291405727 startingPage "104" @default.
• W2291405727 abstract "Since Edward Jenner's discovery that intentional exposure to cowpox could provide lifelong protection from smallpox, vaccinations have been a major focus of medical research. However, while the protective benefits of many vaccines have been successfully translated into the clinic, the cellular and molecular mechanisms that differentiate effective vaccines from sub-optimal ones are not well understood. Dendritic cells (DCs) are the gatekeepers of the immune system, and are ultimately responsible for the generation of adaptive immunity and lifelong protective memory through interactions with T cells. In addition to lymph node and spleen resident DCs, a number of tissue resident DC populations have been identified at barrier tissues, such as the skin, which migrate to the local lymph node (migDC). These populations have unique characteristics, and play a key role in the function of cutaneous vaccinations by shuttling antigen from the vaccination site to the draining lymph node, rapidly capturing freely draining antigens in the lymph node, and providing key stimuli to T cells. However, while migDCs are responsible for the generation of immunity following exposure to certain pathogens and vaccines, recent work has identified a tolerogenic role for migDCs in the steady state as well as during protein immunization. Here, we examine the roles and functions of skin DC populations in the generation of protective immunity, as well as their role as regulators of the immune system." @default.
• W2291405727 created "2016-06-24" @default.
• W2291405727 creator A5044646324 @default.
• W2291405727 creator A5061076537 @default.
• W2291405727 date "2016-01-02" @default.
• W2291405727 modified "2023-10-08" @default.
• W2291405727 title "Duality at the gate: Skin dendritic cells as mediators of vaccine immunity and tolerance" @default.
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