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- W2291412000 abstract "The aim of this study was to asses the effects of high-fat diets with different fatty acid composition on the function of skeletal muscle and liver mitochondria. 12 week old male C57Bl/6J mice were fed either low-fat diet (LFD, 10 kcal% fat from palm oil) or one of three high-fat diets (HFD, 45 kcal% fat from either lard (L), palm oil (PO) or palm oil supplemented with tristearin (POS) ad libitum for 5 weeks (n=8 per diet group)). The content of stearate was similar in HFD(L) and HFD(POS) (15.0% and 13.9%, respectively). Mitochondrial function was assessed using high-resolution respirometry. After 5 weeks of diet body weight was ~20% higher (p<0.001) in all three HFD-fed groups compared to LFD-fed controls. The trend of HFD effects was comparable in skeletal muscle and liver mitochondria. Maximal ADP-stimulated (state 3) oxygen consumption rates were similar in all diet groups when pyruvate plus malate or glutamate plus malate were used as the oxidizible substrates. HFD(L) feeding had no effect on palmitoyl-L-carnitine and stearoyl-L-carnitine-driven oxygen consumption rate in state 3, while HFD(PO) and HFD(POS) feeding led to a significantly higher oxygen consumption rates compared to controls. This observation suggests that fatty acid composition of the dietary fat is important determinant in the HFD feeding-induced mitochondrial adaptations. This work was financed by the Netherlands Consortium for Systems Biology." @default.
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- W2291412000 date "2010-04-01" @default.
- W2291412000 modified "2023-09-27" @default.
- W2291412000 title "Dietary fat‐specific adaptations of mitochondrial function in skeletal muscle and liver of C57Bl/6J mouse" @default.
- W2291412000 doi "https://doi.org/10.1096/fasebj.24.1_supplement.783.1" @default.
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