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• W2291437457 startingPage "716" @default.
• W2291437457 abstract "In recent studies, local specific immunoglobulin E (sIgE) production against allergens in nasal mucosa and a positive response to a nasal allergen provocation test (NAPT) have been demonstrated in some patients initially diagnosed as nonallergic rhinitis (NAR) or idiopathic rhinitis (IR). The aim of this study was to evaluate the presence of local allergic rhinitis (LAR) in patients who experience rhinitis symptoms in indoor and outdoor moldy conditions and to investigate the role of the NAPT in diagnosis.A total of 40 NAR patients with a history of persistent rhinitis and who had negative skin-prick tests (SPTs) and serum sIgE levels to common aeroallergens, as well as 20 healthy subjects were included in the study. NAPTs were performed with Aspergillus fumigatus (group 1) or a mixture of Alternaria alternata and Cladosporium herbarum extracts (group 2).In patient nasal lavage fluids, tryptase and mold sIgE levels were not significantly different from the control group. NAPT with Aspergillus fumigatus was positive in 8 of 12 NAR patients (66.6%) in group 1 and NAPT with the mixture of extracts was positive in 9 of 13 NAR patients (69.2%) in group 2.This study suggests that LAR may exist in a significant number of the persistent rhinitis patients who were previously considered as NAR based on negative SPTs or serum sIgE tests. To the best of our knowledge, this is the first study evaluating a nasal local allergic response to both indoor and outdoor molds." @default.
• W2291437457 created "2016-06-24" @default.
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• W2291437457 date "2016-02-16" @default.
• W2291437457 modified "2023-10-07" @default.
• W2291437457 title "The importance of mold sensitivity in nonallergic rhinitis patients" @default.
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• W2291437457 doi "https://doi.org/10.1002/alr.21731" @default.
• W2291437457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26880361" @default.
• W2291437457 hasPublicationYear "2016" @default.
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