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• W2291490667 abstract "// Tongbao Feng 1, 2, 3 , Fang Shao 1 , Qiyong Wu 3 , Xiaohang Zhang 1 , Dongqin Xu 1 , Keqing Qian 1, 2 , Yewen Xie 1, 2 , Shizhong Wang 1 , Ning Xu 4 , Yong Wang 3 , Chunjian Qi 1, 2 1 Medical Research Center, The Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People’s Hospital, Changzhou, 213003, China 2 Department of Oncology, The Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People’s Hospital, Changzhou, 213003, China 3 Department of General Surgery, the Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People’s Hospital, Changzhou, 213003, China 4 Section of Clinical Chemistry and Pharmacology, Department of Laboratory Medicine, Lund University, S-221 85 Lund, Sweden Correspondence to: Chunjian Qi, e-mail: qichunjian@njmu.edu.cn Keywords: miR-124, MALAT1, cyclin-dependent kinase 4, cell cycle, breast cancer Received: November 01, 2015      Accepted: February 05, 2016      Published: February 22, 2016 ABSTRACT The long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been recently shown to be dysregulated in several cancers. However, the mechanisms underlying the role of MALAT1 in breast cancer remain unclear. Herein, we showed that MALAT1 was aberrantly increased in breast cancer tissues and cells. MALAT1-siRNA inhibited breast cancer cell proliferation and cell cycle progression in vitro and in vivo . Furthermore, MALAT1 acted as an endogenous potent regulator by directly binding to miR-124 and down-regulating miR-124 expression. In addition, MALAT1 reversed the inhibitory effect of miR-124 on breast cancer proliferation and was involved in the cyclin-dependent kinase 4 (CDK4) expression. Taken together, our data highlight the pivotal role of MALAT1 in breast cancer tumorigenesis. Moreover, the present study elucidated the MALAT1-miR-124-CDK4/E2F1 signaling pathway in breast cancer, which might provide a new approach for tackling breast cancer." @default.
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• W2291490667 date "2016-02-22" @default.
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• W2291490667 title "miR-124 downregulation leads to breast cancer progression via LncRNA-MALAT1 regulation and CDK4/E2F1 signal activation" @default.
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• W2291490667 doi "https://doi.org/10.18632/oncotarget.7578" @default.
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