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- W2291492593 abstract "Any advanced shock eventually degenerates into vasoplegia, which responds weakly to vasopressors. The highest reported norepinephrine flow rate is 3 μg/kg/min. We present the case of a young explosion victim, who was transferred in late haemorrhagic shock. Apart from usual treatment (hydration, mass transfusion protocol), single-agent norepinephrine was used to maintain a mean arterial pressure (MAP) of >60-65 mm Hg. For several hours, norepinephrine flow was 7-10 times the aforementioned (highest reported) in order to achieve our goal; during which, further hydration or transfusion would not contribute to MAP elevation. Sequential Organ Failure Assessment (SOFA) severity score was 18 (expected mortality >99%). The patient survived without underperfusion-related damage. We conclude that norepinephrine dosages could potentially be greatly increased in late shock. We must resist giving up flow escalation based on its numerical value." @default.
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- W2291492593 date "2016-03-04" @default.
- W2291492593 modified "2023-09-23" @default.
- W2291492593 title "Should the norepinephrine maximal dosage rate be greatly increased in late shock?" @default.
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- W2291492593 doi "https://doi.org/10.1136/bcr-2015-213670" @default.
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