FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2291552992> ?p ?o ?g. }

• W2291552992 endingPage "83" @default.
• W2291552992 startingPage "672" @default.
• W2291552992 abstract "We examined the involvement of multiple monoaminergic receptors in the induction of spontaneous tail-flicks (STFs) by the open channel blocker at N-methyl-D-aspartate (NMDA) receptors, dizocilpine, and the NMDA recognition site antagonist 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP). At doses eliciting a maximal STF response, dizocilpine and CPP elevated levels of norepinephrine, but not dopamine or serotonin, in dialysates of nucleus accumbens, their known locus of action in eliciting STFs. Chemically diverse alpha(2)-adrenergic receptor (AR) antagonists atipamezole, L745,743, RX821,002, idazoxan, and desfluparoxan abolished induction of STFs by dizocilpine, whereas the preferential alpha(1)-AR antagonists prazosin, WB4101, and ARC239 were weakly active: relative potencies in blocking STFs correlated significantly with affinity at alpha(2)-ARs. The D(1)/D(5) receptor antagonists SCH23390, SCH39166, and NNC756 potently abolished STFs, whereas the D(2) antagonist L741,626, the D(3) antagonists GR218,231 and S14297, and the D(4) antagonists S18126 and L745,870 were inactive. D(1) and alpha(2)-AR antagonists also blocked induction of STFs by CPP. Blockade of dizocilpine-induced STFs was specific inasmuch as idazoxan and SCH 23390 did not modify induction of ataxia by dizocilpine. Antagonists at multiple 5-hydroxytryptamine receptors failed to modify induction of STFs. Finally, dizocilpine-induced STFs were blocked by clozapine and 11 other antipsychotics, the potency of which correlated significantly with affinity at alpha(2)-ARs. In conclusion, STFs evoked by interruption of transmission at NMDA receptors are dependent on D(1) receptors and alpha(2)-ARs for their expression. Antagonism of the alpha(2)-ARs is involved in their blockade by antipsychotics. This model should facilitate exploration of interrelationships between glutamatergic and monoaminergic mechanisms involved in psychiatric and neurologic disorders." @default.
• W2291552992 created "2016-06-24" @default.
• W2291552992 creator A5015680710 @default.
• W2291552992 creator A5038806903 @default.
• W2291552992 creator A5039339834 @default.
• W2291552992 creator A5041008066 @default.
• W2291552992 creator A5041494494 @default.
• W2291552992 creator A5058418331 @default.
• W2291552992 date "2000-02-01" @default.
• W2291552992 modified "2023-09-23" @default.
• W2291552992 title "Induction of spontaneous tail-flicks in rats by blockade of transmission at N-methyl-D-aspartate receptors: roles of multiple monoaminergic receptors in relation to the actions of antipsychotic agents." @default.
• W2291552992 cites W1720397775 @default.
• W2291552992 cites W1880198815 @default.
• W2291552992 cites W1895729847 @default.
• W2291552992 cites W1965194593 @default.
• W2291552992 cites W1969134234 @default.
• W2291552992 cites W1971851906 @default.
• W2291552992 cites W1974629156 @default.
• W2291552992 cites W1982539986 @default.
• W2291552992 cites W1985161962 @default.
• W2291552992 cites W1988836643 @default.
• W2291552992 cites W1994219935 @default.
• W2291552992 cites W1999649044 @default.
• W2291552992 cites W2002596676 @default.
• W2291552992 cites W2005084287 @default.
• W2291552992 cites W2020649642 @default.
• W2291552992 cites W2021865713 @default.
• W2291552992 cites W2023358654 @default.
• W2291552992 cites W2023574451 @default.
• W2291552992 cites W2025186774 @default.
• W2291552992 cites W2027437909 @default.
• W2291552992 cites W2027610146 @default.
• W2291552992 cites W2027709174 @default.
• W2291552992 cites W2031416246 @default.
• W2291552992 cites W2033484161 @default.
• W2291552992 cites W2039800019 @default.
• W2291552992 cites W2042850454 @default.
• W2291552992 cites W2048436669 @default.
• W2291552992 cites W2052378705 @default.
• W2291552992 cites W2052996136 @default.
• W2291552992 cites W2053752634 @default.
• W2291552992 cites W2053904036 @default.
• W2291552992 cites W2055503105 @default.
• W2291552992 cites W2063164578 @default.
• W2291552992 cites W2064598049 @default.
• W2291552992 cites W2066274668 @default.
• W2291552992 cites W2080444163 @default.
• W2291552992 cites W2086630929 @default.
• W2291552992 cites W2086687352 @default.
• W2291552992 cites W2086759702 @default.
• W2291552992 cites W2089938602 @default.
• W2291552992 cites W2090252372 @default.
• W2291552992 cites W2093305907 @default.
• W2291552992 cites W2093900681 @default.
• W2291552992 cites W2101048773 @default.
• W2291552992 cites W2101835376 @default.
• W2291552992 cites W2116634575 @default.
• W2291552992 cites W2123268199 @default.
• W2291552992 cites W2130795067 @default.
• W2291552992 cites W2142960003 @default.
• W2291552992 cites W2150167216 @default.
• W2291552992 cites W2151467871 @default.
• W2291552992 cites W2243344362 @default.
• W2291552992 cites W2264009361 @default.
• W2291552992 cites W2285924403 @default.
• W2291552992 cites W2300532463 @default.
• W2291552992 cites W2303408262 @default.
• W2291552992 cites W2318210124 @default.
• W2291552992 cites W585072357 @default.
• W2291552992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10640305" @default.
• W2291552992 hasPublicationYear "2000" @default.
• W2291552992 type Work @default.
• W2291552992 sameAs 2291552992 @default.
• W2291552992 citedByCount "0" @default.
• W2291552992 crossrefType "journal-article" @default.
• W2291552992 hasAuthorship W2291552992A5015680710 @default.
• W2291552992 hasAuthorship W2291552992A5038806903 @default.
• W2291552992 hasAuthorship W2291552992A5039339834 @default.
• W2291552992 hasAuthorship W2291552992A5041008066 @default.
• W2291552992 hasAuthorship W2291552992A5041494494 @default.
• W2291552992 hasAuthorship W2291552992A5058418331 @default.
• W2291552992 hasConcept C126322002 @default.
• W2291552992 hasConcept C134018914 @default.
• W2291552992 hasConcept C170493617 @default.
• W2291552992 hasConcept C185592680 @default.
• W2291552992 hasConcept C2776885963 @default.
• W2291552992 hasConcept C2777836312 @default.
• W2291552992 hasConcept C2778938600 @default.
• W2291552992 hasConcept C2780648677 @default.
• W2291552992 hasConcept C2780939551 @default.
• W2291552992 hasConcept C55493867 @default.
• W2291552992 hasConcept C67018056 @default.
• W2291552992 hasConcept C71924100 @default.
• W2291552992 hasConcept C86803240 @default.
• W2291552992 hasConcept C98274493 @default.
• W2291552992 hasConceptScore W2291552992C126322002 @default.
• W2291552992 hasConceptScore W2291552992C134018914 @default.
• W2291552992 hasConceptScore W2291552992C170493617 @default.

• next