Matches in SemOpenAlex for { <https://semopenalex.org/work/W2291558592> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2291558592 abstract "Drugs take effect at different times in different individuals. Consequently, researchers seek to examine how the timing of the biological response to drugs may be affected by factors such as gender, genotypes, age, or baseline symptom scores.Typically, studies measure symptoms immediately after the initiation of drug treatment and then at a sequence of later time points. In this study, we develop a statistical mixture model for analyzing such longitudinal data. Our method estimates the onset of drug effect and assesses the association between the probability distribution of the onset times and possible contributing factors. Our mixture model treats the timing of onset as missing for each individual but restricts it, for simplicity, to two possible onset points, early or late. To estimate the model, we use an expectation-maximization-based approach and provide the general formulas of the variance and covariance matrix for the estimated parameters.We evaluate the model's overall utility and performance via simulation studies. In addition, we illustrate its use by application to longitudinal data from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. The algorithm identified age and anxiety status as significant factors in affecting the onset distribution of citalopram (Celexa)." @default.
- W2291558592 created "2016-06-24" @default.
- W2291558592 creator A5036278452 @default.
- W2291558592 creator A5059073252 @default.
- W2291558592 creator A5065169459 @default.
- W2291558592 creator A5090618642 @default.
- W2291558592 creator A5091418738 @default.
- W2291558592 date "2015-01-01" @default.
- W2291558592 modified "2023-09-26" @default.
- W2291558592 title "A Novel Mixture Model to Estimate the Time to Drug Effect Onset and Its Association with Covariates" @default.
- W2291558592 cites W1587094587 @default.
- W2291558592 cites W1967639437 @default.
- W2291558592 cites W1982217406 @default.
- W2291558592 cites W1986382748 @default.
- W2291558592 cites W2000053835 @default.
- W2291558592 cites W2029761439 @default.
- W2291558592 cites W2049633694 @default.
- W2291558592 cites W2052345510 @default.
- W2291558592 cites W2114613490 @default.
- W2291558592 cites W2138876346 @default.
- W2291558592 cites W2146659162 @default.
- W2291558592 cites W2149402043 @default.
- W2291558592 cites W2400600349 @default.
- W2291558592 cites W639907764 @default.
- W2291558592 doi "https://doi.org/10.1159/000440880" @default.
- W2291558592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26771572" @default.
- W2291558592 hasPublicationYear "2015" @default.
- W2291558592 type Work @default.
- W2291558592 sameAs 2291558592 @default.
- W2291558592 citedByCount "0" @default.
- W2291558592 crossrefType "journal-article" @default.
- W2291558592 hasAuthorship W2291558592A5036278452 @default.
- W2291558592 hasAuthorship W2291558592A5059073252 @default.
- W2291558592 hasAuthorship W2291558592A5065169459 @default.
- W2291558592 hasAuthorship W2291558592A5090618642 @default.
- W2291558592 hasAuthorship W2291558592A5091418738 @default.
- W2291558592 hasConcept C102959455 @default.
- W2291558592 hasConcept C105795698 @default.
- W2291558592 hasConcept C119043178 @default.
- W2291558592 hasConcept C126255220 @default.
- W2291558592 hasConcept C139719470 @default.
- W2291558592 hasConcept C142853389 @default.
- W2291558592 hasConcept C149782125 @default.
- W2291558592 hasConcept C15744967 @default.
- W2291558592 hasConcept C162324750 @default.
- W2291558592 hasConcept C178650346 @default.
- W2291558592 hasConcept C182081679 @default.
- W2291558592 hasConcept C2776330181 @default.
- W2291558592 hasConcept C2776867660 @default.
- W2291558592 hasConcept C33923547 @default.
- W2291558592 hasConcept C41008148 @default.
- W2291558592 hasConcept C49781872 @default.
- W2291558592 hasConcept C542102704 @default.
- W2291558592 hasConcept C71924100 @default.
- W2291558592 hasConceptScore W2291558592C102959455 @default.
- W2291558592 hasConceptScore W2291558592C105795698 @default.
- W2291558592 hasConceptScore W2291558592C119043178 @default.
- W2291558592 hasConceptScore W2291558592C126255220 @default.
- W2291558592 hasConceptScore W2291558592C139719470 @default.
- W2291558592 hasConceptScore W2291558592C142853389 @default.
- W2291558592 hasConceptScore W2291558592C149782125 @default.
- W2291558592 hasConceptScore W2291558592C15744967 @default.
- W2291558592 hasConceptScore W2291558592C162324750 @default.
- W2291558592 hasConceptScore W2291558592C178650346 @default.
- W2291558592 hasConceptScore W2291558592C182081679 @default.
- W2291558592 hasConceptScore W2291558592C2776330181 @default.
- W2291558592 hasConceptScore W2291558592C2776867660 @default.
- W2291558592 hasConceptScore W2291558592C33923547 @default.
- W2291558592 hasConceptScore W2291558592C41008148 @default.
- W2291558592 hasConceptScore W2291558592C49781872 @default.
- W2291558592 hasConceptScore W2291558592C542102704 @default.
- W2291558592 hasConceptScore W2291558592C71924100 @default.
- W2291558592 hasLocation W22915585921 @default.
- W2291558592 hasLocation W22915585922 @default.
- W2291558592 hasOpenAccess W2291558592 @default.
- W2291558592 hasPrimaryLocation W22915585921 @default.
- W2291558592 hasRelatedWork W1444088 @default.
- W2291558592 hasRelatedWork W2034945547 @default.
- W2291558592 hasRelatedWork W2066738518 @default.
- W2291558592 hasRelatedWork W2089510282 @default.
- W2291558592 hasRelatedWork W2111184408 @default.
- W2291558592 hasRelatedWork W2116796884 @default.
- W2291558592 hasRelatedWork W2181991789 @default.
- W2291558592 hasRelatedWork W2187280242 @default.
- W2291558592 hasRelatedWork W2259735982 @default.
- W2291558592 hasRelatedWork W2267471850 @default.
- W2291558592 hasRelatedWork W2578330703 @default.
- W2291558592 hasRelatedWork W2735127225 @default.
- W2291558592 hasRelatedWork W2968938401 @default.
- W2291558592 hasRelatedWork W3005140791 @default.
- W2291558592 hasRelatedWork W3019802853 @default.
- W2291558592 hasRelatedWork W3125518628 @default.
- W2291558592 hasRelatedWork W3180729426 @default.
- W2291558592 hasRelatedWork W3197587210 @default.
- W2291558592 hasRelatedWork W625565276 @default.
- W2291558592 hasRelatedWork W2349641585 @default.
- W2291558592 isParatext "false" @default.
- W2291558592 isRetracted "false" @default.
- W2291558592 magId "2291558592" @default.
- W2291558592 workType "article" @default.