Matches in SemOpenAlex for { <https://semopenalex.org/work/W2291574503> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2291574503 endingPage "36.61" @default.
- W2291574503 startingPage "36.61" @default.
- W2291574503 abstract "Abstract The T-cell receptor (TCR) is encoded by tandem arrays of variable (V), diversity (D), and joining (J) gene segments that are somatically rearranged during thymic development. During this process the RAG recombinase introduces transient DNA double strand breaks (DSBs) which are repaired by non-homologous end joining (NHEJ). Additionally, the DSBs are detected by components of the cellular DNA damage response (DDR) which bind to the chromatin within 1 megabase of the break forming foci. One component of DDR, Ataxia Telangiectasia mutated (ATM), plays a major role in activating downstream effectors involved in apoptosis, cell cycle arrest and DNA repair. ATM-deficiency is characterized by reduced rearrangement at the TCR-α locus in CD4/CD8 double positive (DP) thymocytes, high frequency of thymic lymphomas carrying translocations at the TCR-α locus, and increased frequency of TCR-β/TCR-γ trans-rearrangements. Since TCR-β, γ and δ recombination occurs in CD4/CD8 double negative (DN) cells, we examined the effect of ATM deficiency on these rearrangements. We found that rearrangement is impaired at the TCR-β, γ and δ loci. We also demonstrate increased frequency of TCR-β/TCR-γ trans-rearrangements in ATM deficient cells. Such trans-rearrangements may be the result of concurrent recombination at multiple TCR loci in DN cells. We are currently testing this hypothesis using combined immunofluorescence detection of DDR foci and fluorescent in situ hybridization of TCR loci." @default.
- W2291574503 created "2016-06-24" @default.
- W2291574503 creator A5043529917 @default.
- W2291574503 creator A5046390137 @default.
- W2291574503 creator A5068842902 @default.
- W2291574503 creator A5072102205 @default.
- W2291574503 date "2010-04-01" @default.
- W2291574503 modified "2023-09-25" @default.
- W2291574503 title "Normal and Pathological Regulation of DNA Damage Response to T-cell Receptor Gene Rearrangement (36.61)" @default.
- W2291574503 doi "https://doi.org/10.4049/jimmunol.184.supp.36.61" @default.
- W2291574503 hasPublicationYear "2010" @default.
- W2291574503 type Work @default.
- W2291574503 sameAs 2291574503 @default.
- W2291574503 citedByCount "0" @default.
- W2291574503 crossrefType "journal-article" @default.
- W2291574503 hasAuthorship W2291574503A5043529917 @default.
- W2291574503 hasAuthorship W2291574503A5046390137 @default.
- W2291574503 hasAuthorship W2291574503A5068842902 @default.
- W2291574503 hasAuthorship W2291574503A5072102205 @default.
- W2291574503 hasConcept C102414288 @default.
- W2291574503 hasConcept C104317684 @default.
- W2291574503 hasConcept C113646796 @default.
- W2291574503 hasConcept C134935766 @default.
- W2291574503 hasConcept C143425029 @default.
- W2291574503 hasConcept C153911025 @default.
- W2291574503 hasConcept C156695909 @default.
- W2291574503 hasConcept C167672396 @default.
- W2291574503 hasConcept C19317047 @default.
- W2291574503 hasConcept C2776090121 @default.
- W2291574503 hasConcept C2779486608 @default.
- W2291574503 hasConcept C2780254951 @default.
- W2291574503 hasConcept C2992511266 @default.
- W2291574503 hasConcept C54355233 @default.
- W2291574503 hasConcept C552990157 @default.
- W2291574503 hasConcept C83640560 @default.
- W2291574503 hasConcept C86803240 @default.
- W2291574503 hasConcept C8891405 @default.
- W2291574503 hasConcept C95444343 @default.
- W2291574503 hasConceptScore W2291574503C102414288 @default.
- W2291574503 hasConceptScore W2291574503C104317684 @default.
- W2291574503 hasConceptScore W2291574503C113646796 @default.
- W2291574503 hasConceptScore W2291574503C134935766 @default.
- W2291574503 hasConceptScore W2291574503C143425029 @default.
- W2291574503 hasConceptScore W2291574503C153911025 @default.
- W2291574503 hasConceptScore W2291574503C156695909 @default.
- W2291574503 hasConceptScore W2291574503C167672396 @default.
- W2291574503 hasConceptScore W2291574503C19317047 @default.
- W2291574503 hasConceptScore W2291574503C2776090121 @default.
- W2291574503 hasConceptScore W2291574503C2779486608 @default.
- W2291574503 hasConceptScore W2291574503C2780254951 @default.
- W2291574503 hasConceptScore W2291574503C2992511266 @default.
- W2291574503 hasConceptScore W2291574503C54355233 @default.
- W2291574503 hasConceptScore W2291574503C552990157 @default.
- W2291574503 hasConceptScore W2291574503C83640560 @default.
- W2291574503 hasConceptScore W2291574503C86803240 @default.
- W2291574503 hasConceptScore W2291574503C8891405 @default.
- W2291574503 hasConceptScore W2291574503C95444343 @default.
- W2291574503 hasIssue "1_Supplement" @default.
- W2291574503 hasLocation W22915745031 @default.
- W2291574503 hasOpenAccess W2291574503 @default.
- W2291574503 hasPrimaryLocation W22915745031 @default.
- W2291574503 hasRelatedWork W124715810 @default.
- W2291574503 hasRelatedWork W2038920975 @default.
- W2291574503 hasRelatedWork W2107868425 @default.
- W2291574503 hasRelatedWork W2109581539 @default.
- W2291574503 hasRelatedWork W2269268253 @default.
- W2291574503 hasRelatedWork W2291574503 @default.
- W2291574503 hasRelatedWork W2312156852 @default.
- W2291574503 hasRelatedWork W2398761222 @default.
- W2291574503 hasRelatedWork W3083574247 @default.
- W2291574503 hasRelatedWork W95963776 @default.
- W2291574503 hasVolume "184" @default.
- W2291574503 isParatext "false" @default.
- W2291574503 isRetracted "false" @default.
- W2291574503 magId "2291574503" @default.
- W2291574503 workType "article" @default.