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- W2291581609 abstract "Nanoparticles (NP) are tiny materials that have specific physicochemical properties different to bulk materials of same composition and such properties make them very attractive for commercial and medical development. The aim of this work was to produce and characterize Repaglinide (Rg) engineered Ethyl Cellulose NP by the solvent evaporation model, in an attempt to obtain a novel delivery system adequate for the treatment of diabetes. Batches were prepared with different ratios of drug and polymer in order to evaluate the influence of drug on NP properties. The absence of any chemical interaction between drug and polymer was confirmed by Fourier Transform Infra Red spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC) and Thermo Gravimetric Analysis (TGA) techniques. X-Ray Diffraction pattern of formulation confirmed the superimposition of polymer and drug with lower intensity. The average diameter of NP determined by Photon Correlation Spectroscopy (PCS) was about 100nm. NP showed 86.4% Encapsulation Efficiency (EE) and 9.61% drug loading. Finally, the in-vitro release profile observed for these NP was characterized by a delayed release phase. Questions about the potential haemolytic activity of formulated nanoparticles i.e., cytotoxicity was proved by our results. Interestingly, these results suggest that nano encapsulation of the drug in biodegradable, biocompatible polymer will improve its pharmacological significance." @default.
- W2291581609 created "2016-06-24" @default.
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- W2291581609 date "2012-01-01" @default.
- W2291581609 modified "2023-10-17" @default.
- W2291581609 title "IN-VITRO OBSERVATION OF REPAGLINIDE ENGINEERED POLYMERIC NANOPARTICLES" @default.
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