Matches in SemOpenAlex for { <https://semopenalex.org/work/W229162911> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W229162911 abstract "An analogue of hGH isolated from plerocercoids of the tapeworm Spirometra mansonoides displaces (/sup 125/I)hGH from its receptors in rabbit, rat, and hamster liver membranes. Biologically, plerocercoid growth factor (PGF) is more similar to hGH than to other mammalian GH's but has not been shown to bond human cells. Receptors specific for hGH have been described on cultured human lymphocytes (IM-9). In this study, the authors compared the binding of PGF and hGH in IM-9 cells and in rabbit hepatic membranes. IM-9 lymphocytes (12 x 10/sup 6/ cells/tube) were incubated with (/sup 125/I)hGH and increasing concentrations of hGH (ng/ml) or PGF (serial dilutions) for 90 min at 30/sup 0/ C. Specific binding (B/sub 0/ - NSB) was determined for each dose of hGH or PGF and the binding curves were analyzed by logit-log regression. The results show that PGF displaced (/sup 125/I)hGH from human cells in a dose dependent manner (r = 0.98). Based on the IM-9 assay, 1 ml of the PGF had an activity equivalent to 625 ng of the hGH standard (ngE). However, the binding activity of the PGF in the rabbit liver RRA was 1653 ngE/ml, indicating that the binding potency of PGF in IM-9 cellsmore » was only 38% of that in the rabbit liver. These results clearly demonstrate that PGF binds hGH receptors in cells of human origin, suggesting that PGF will be effective in humans.« less" @default.
- W229162911 created "2016-06-24" @default.
- W229162911 creator A5044908351 @default.
- W229162911 creator A5064824295 @default.
- W229162911 date "1986-03-01" @default.
- W229162911 modified "2023-09-23" @default.
- W229162911 title "Growth hormone-like factor produced by the tapeworm, Spirometra mansonoides, displaces human growth hormone (hGH) from its receptors on cultured human lymphocytes" @default.
- W229162911 hasPublicationYear "1986" @default.
- W229162911 type Work @default.
- W229162911 sameAs 229162911 @default.
- W229162911 citedByCount "1" @default.
- W229162911 crossrefType "journal-article" @default.
- W229162911 hasAuthorship W229162911A5044908351 @default.
- W229162911 hasAuthorship W229162911A5064824295 @default.
- W229162911 hasConcept C126322002 @default.
- W229162911 hasConcept C134018914 @default.
- W229162911 hasConcept C142724271 @default.
- W229162911 hasConcept C153911025 @default.
- W229162911 hasConcept C170493617 @default.
- W229162911 hasConcept C184112429 @default.
- W229162911 hasConcept C204787440 @default.
- W229162911 hasConcept C55493867 @default.
- W229162911 hasConcept C71924100 @default.
- W229162911 hasConcept C86803240 @default.
- W229162911 hasConceptScore W229162911C126322002 @default.
- W229162911 hasConceptScore W229162911C134018914 @default.
- W229162911 hasConceptScore W229162911C142724271 @default.
- W229162911 hasConceptScore W229162911C153911025 @default.
- W229162911 hasConceptScore W229162911C170493617 @default.
- W229162911 hasConceptScore W229162911C184112429 @default.
- W229162911 hasConceptScore W229162911C204787440 @default.
- W229162911 hasConceptScore W229162911C55493867 @default.
- W229162911 hasConceptScore W229162911C71924100 @default.
- W229162911 hasConceptScore W229162911C86803240 @default.
- W229162911 hasLocation W2291629111 @default.
- W229162911 hasOpenAccess W229162911 @default.
- W229162911 hasPrimaryLocation W2291629111 @default.
- W229162911 hasRelatedWork W1494333606 @default.
- W229162911 hasRelatedWork W1589680933 @default.
- W229162911 hasRelatedWork W1970619340 @default.
- W229162911 hasRelatedWork W1972698545 @default.
- W229162911 hasRelatedWork W1975286415 @default.
- W229162911 hasRelatedWork W1975821655 @default.
- W229162911 hasRelatedWork W1981947728 @default.
- W229162911 hasRelatedWork W1991908234 @default.
- W229162911 hasRelatedWork W2011726222 @default.
- W229162911 hasRelatedWork W2017247290 @default.
- W229162911 hasRelatedWork W2043613993 @default.
- W229162911 hasRelatedWork W2057796312 @default.
- W229162911 hasRelatedWork W2072703482 @default.
- W229162911 hasRelatedWork W2092379856 @default.
- W229162911 hasRelatedWork W2096238245 @default.
- W229162911 hasRelatedWork W2097303048 @default.
- W229162911 hasRelatedWork W2141951155 @default.
- W229162911 hasRelatedWork W2152334607 @default.
- W229162911 hasRelatedWork W2325877772 @default.
- W229162911 hasRelatedWork W2418400216 @default.
- W229162911 isParatext "false" @default.
- W229162911 isRetracted "false" @default.
- W229162911 magId "229162911" @default.
- W229162911 workType "article" @default.