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- W2291662050 abstract "We present a method which can evaluate stiffness of cell-spheroids, and show the measurement results of the stiffness changes with respect to the culture time. To obtain the stiffness-index map, where the map shows the relationship between the size and stiffness of cell-spheroids, we applied on-chip measurement method using a robot integrated microfluidic chip (robochip). The robochip has a microchannel and a pair of on-chip probes which contains a force sensor. By measuring the stiffness in microfluidic channel, we can achieve a stable and high-throughput evaluation of mechanical characteristics. The stiffness of the single spheroid is evaluated from the reactive force when the target spheroid is deformed by the on-chip probes. The stiffness-index of cell-spheroid is proposed, and the evaluation results of the stiffness index shows that the index increased along the culture days. The proposed system will provide us a new index for the cell-quality evaluation." @default.
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- W2291662050 date "2016-01-01" @default.
- W2291662050 modified "2023-09-24" @default.
- W2291662050 title "Stiffness-index map based on single cell-spheroid analysis using robot integrated microfluidic chiip" @default.
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- W2291662050 doi "https://doi.org/10.1109/memsys.2016.7421582" @default.
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