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- W2291680846 abstract "Background: Vasopressin type2 receptor(V2R)plays an important role in thewater reabsorption in the kidney collecting ducts .V2R is aG protein coupled receptor (GPCR) andthe triplet of amino acids aspartatearginine-histidine(DRH) inthis receptor might significantly influence its activity similar to other GPCR. However,the role of this motif has not been fully confirmed. Therefore, thepresent study attempted to shed some more light on the role of DRH motif in Gprotein coupling and V 2R functionwith the use of site directedmutagenesis.Methods: Nested PCR using specific primers was used to produ ce DNA fragments containingaspartate-lysine-isoleucineand aspartate-arginine-tyrosinemutationswith replacements of the arginine to lysine and histidineto tyrosine , respectively . After digestion, thesewere ligated into the pcDNA 3vectorand transformation into E.coliHB101 was performed using heat shock method .The obtained colonies were analyzed for the presence and orientation of the inserts using proper restriction enzymes. After" @default.
- W2291680846 created "2016-06-24" @default.
- W2291680846 creator A5065815407 @default.
- W2291680846 date "2010-01-15" @default.
- W2291680846 modified "2023-09-28" @default.
- W2291680846 title "The effect of aspartate-lysine-isoleucine and aspartate-arginine-tyrosine mutations on the expression and activity of vasopressin V2 receptor gene." @default.
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