FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2291689896> ?p ?o ?g. }

• W2291689896 endingPage "3301" @default.
• W2291689896 startingPage "3294" @default.
• W2291689896 abstract "To address the fundamental question of whether or not stem cell populations age, we performed quantitative measurements of the cycling status and frequency of hematopoietic stem cells in long-lived C57BL/6 (B6) and short-lived DBA/2 (DBA) mice at different developmental and aging stages. The frequency of cobblestone area-forming cells (CAFC) day-35 in DBA fetal liver was twofold to threefold higher than in B6 mice, and by late gestation, the total stem cell number was nearly as large as that of young DBA adults. Following a further ≈50% increase in stem cells between 6 weeks and 1 year of age, numbers in old DBA mice dropped precipitously between 12 and 20 months of age. In marked contrast, this stem cell population in B6 mice increased at a constant rate from late gestation to 20 months of age with no signs of abatement. Throughout development an inverse correlation was observed between stem cell numbers and the percentage of cells in S-phase. Because a strong genetic component contributed to the changes in stem cell numbers during aging, we quantified stem cells of 20-month old BXD recombinant inbred (RI) mice, derived from B6 and DBA progenitor strains, thus permitting detailed interstrain genetic analysis. For each BXD strain we calculated the stem cell increase or decrease as mice aged from 2 to 20 months. Net changes in CAFC-day 35 numbers among BXD strains ranged from an ≈10-fold decrease to an ≈10-fold increase. A genome-wide search for loci associated with this quantitative trait was performed. Several loci contribute to the trait—putative loci map to chromosomes X, 2, and 14. We conclude that stem cell numbers fluctuate widely during aging and that this has a strong genetic basis." @default.
• W2291689896 created "2016-06-24" @default.
• W2291689896 creator A5052623136 @default.
• W2291689896 creator A5063070865 @default.
• W2291689896 date "1999-05-15" @default.
• W2291689896 modified "2023-10-10" @default.
• W2291689896 title "Dynamic Changes in Mouse Hematopoietic Stem Cell Numbers During Aging" @default.
• W2291689896 cites W1495834791 @default.
• W2291689896 cites W1509946101 @default.
• W2291689896 cites W1558342973 @default.
• W2291689896 cites W176973267 @default.
• W2291689896 cites W1969635787 @default.
• W2291689896 cites W1973577066 @default.
• W2291689896 cites W1976741643 @default.
• W2291689896 cites W1985801522 @default.
• W2291689896 cites W1986382985 @default.
• W2291689896 cites W1992235404 @default.
• W2291689896 cites W1998566378 @default.
• W2291689896 cites W1998663807 @default.
• W2291689896 cites W2011779395 @default.
• W2291689896 cites W2015524565 @default.
• W2291689896 cites W2016375553 @default.
• W2291689896 cites W2025535815 @default.
• W2291689896 cites W2028595453 @default.
• W2291689896 cites W2028835250 @default.
• W2291689896 cites W2034311985 @default.
• W2291689896 cites W2046249192 @default.
• W2291689896 cites W2059626630 @default.
• W2291689896 cites W2068409711 @default.
• W2291689896 cites W2071065596 @default.
• W2291689896 cites W2072367160 @default.
• W2291689896 cites W2083632015 @default.
• W2291689896 cites W2084211300 @default.
• W2291689896 cites W2085184588 @default.
• W2291689896 cites W2093264415 @default.
• W2291689896 cites W2095252752 @default.
• W2291689896 cites W2107701248 @default.
• W2291689896 cites W2108482850 @default.
• W2291689896 cites W2110116124 @default.
• W2291689896 cites W2115154817 @default.
• W2291689896 cites W2123466824 @default.
• W2291689896 cites W2125860227 @default.
• W2291689896 cites W2131958173 @default.
• W2291689896 cites W2148459495 @default.
• W2291689896 cites W2150080365 @default.
• W2291689896 cites W2166846044 @default.
• W2291689896 cites W2397998293 @default.
• W2291689896 cites W2411802233 @default.
• W2291689896 cites W2413036373 @default.
• W2291689896 cites W9231455 @default.
• W2291689896 cites W97711432 @default.
• W2291689896 doi "https://doi.org/10.1182/blood.v93.10.3294.410k07_3294_3301" @default.
• W2291689896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10233881" @default.
• W2291689896 hasPublicationYear "1999" @default.
• W2291689896 type Work @default.
• W2291689896 sameAs 2291689896 @default.
• W2291689896 citedByCount "201" @default.
• W2291689896 countsByYear W22916898962012 @default.
• W2291689896 countsByYear W22916898962013 @default.
• W2291689896 countsByYear W22916898962014 @default.
• W2291689896 countsByYear W22916898962015 @default.
• W2291689896 countsByYear W22916898962016 @default.
• W2291689896 countsByYear W22916898962017 @default.
• W2291689896 countsByYear W22916898962018 @default.
• W2291689896 countsByYear W22916898962019 @default.
• W2291689896 countsByYear W22916898962020 @default.
• W2291689896 countsByYear W22916898962021 @default.
• W2291689896 countsByYear W22916898962022 @default.
• W2291689896 countsByYear W22916898962023 @default.
• W2291689896 crossrefType "journal-article" @default.
• W2291689896 hasAuthorship W2291689896A5052623136 @default.
• W2291689896 hasAuthorship W2291689896A5063070865 @default.
• W2291689896 hasConcept C109159458 @default.
• W2291689896 hasConcept C14218858 @default.
• W2291689896 hasConcept C16685009 @default.
• W2291689896 hasConcept C201750760 @default.
• W2291689896 hasConcept C2022786 @default.
• W2291689896 hasConcept C203014093 @default.
• W2291689896 hasConcept C2778086970 @default.
• W2291689896 hasConcept C28328180 @default.
• W2291689896 hasConcept C2908647359 @default.
• W2291689896 hasConcept C54355233 @default.
• W2291689896 hasConcept C71924100 @default.
• W2291689896 hasConcept C86803240 @default.
• W2291689896 hasConcept C99454951 @default.
• W2291689896 hasConceptScore W2291689896C109159458 @default.
• W2291689896 hasConceptScore W2291689896C14218858 @default.
• W2291689896 hasConceptScore W2291689896C16685009 @default.
• W2291689896 hasConceptScore W2291689896C201750760 @default.
• W2291689896 hasConceptScore W2291689896C2022786 @default.
• W2291689896 hasConceptScore W2291689896C203014093 @default.
• W2291689896 hasConceptScore W2291689896C2778086970 @default.
• W2291689896 hasConceptScore W2291689896C28328180 @default.
• W2291689896 hasConceptScore W2291689896C2908647359 @default.
• W2291689896 hasConceptScore W2291689896C54355233 @default.
• W2291689896 hasConceptScore W2291689896C71924100 @default.
• W2291689896 hasConceptScore W2291689896C86803240 @default.
• W2291689896 hasConceptScore W2291689896C99454951 @default.

• next