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- W2291744544 abstract "The regulation of phosphate metabolism as an influence on bone homeostasis is profound. Recent advances in understanding the systemic control of fibroblast growth factor-23 (FGF23) has uncovered novel effectors of endocrine feedback loops for calcium, phosphate, and vitamin D balance that interact with ‘traditional’ feedback loops for mineral metabolism. Not only are these findings reshaping research studying phosphate handling and skeletal interactions, but they have also provided new therapeutic interventions. Emerging data support that the control of FGF23 production in bone and its circulating concentrations is a multilayered process, with some influences affecting FGF23 transcription and some posttranslational modification of the secreted, bioactive protein. Additionally, the actions of FGF23 on its target tissues via its coreceptor α-Klotho, are subject to regulatory events just coming to light. The recent findings of systemic influences on circulating FGF23 and the downstream manifestations on bone homeostasis will be reviewed herein." @default.
- W2291744544 created "2016-06-24" @default.
- W2291744544 creator A5031267390 @default.
- W2291744544 creator A5052508119 @default.
- W2291744544 date "2016-02-03" @default.
- W2291744544 modified "2023-10-18" @default.
- W2291744544 title "Systemic Control of Bone Homeostasis by FGF23 Signaling" @default.
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- W2291744544 doi "https://doi.org/10.1007/s40610-016-0035-5" @default.
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