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• W2291767516 startingPage "1145" @default.
• W2291767516 abstract "The human gastrointestinal (GI) microbiota plays an important role in human health. Anaerobic bacteria prevalent in the normal colon suppress the growth of non-commensal microorganisms, thus maintaining colonic homeostasis. The GI microbiota is influenced by both patient-specific and environmental factors, particularly antibiotics. Antibiotics can alter the native GI microbiota composition, leading to decreased colonization resistance and opportunistic proliferation of non-native organisms. A common and potentially serious antibiotic-induced sequela associated with GI microbiota imbalance is Clostridium difficile infection (CDI), which may become recurrent if dysbiosis persists. This review focuses on the association between antibiotics and CDI, and the antibiotic-induced disruption leading to recurrent CDI. Promoting antibiotic stewardship is pivotal in protecting native microbiota and reducing the incidence of CDI and other GI infections." @default.
• W2291767516 created "2016-06-24" @default.
• W2291767516 creator A5016245381 @default.
• W2291767516 creator A5077792271 @default.
• W2291767516 date "2016-03-16" @default.
• W2291767516 modified "2023-10-03" @default.
• W2291767516 title "Clinical implications of antibiotic impact on gastrointestinal microbiota and<i>Clostridium difficile</i>infection" @default.
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• W2291767516 doi "https://doi.org/10.1586/17474124.2016.1158097" @default.
• W2291767516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26907220" @default.
• W2291767516 hasPublicationYear "2016" @default.
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