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- W2291787173 abstract "Background. Improved knowledge on the relationships between the cervicovaginal microbiome and adverse reproductive health outcomes could lead to low cost interventions directed at maintaining and restoring a healthy microbiome.Methods. Cervical samples of 174 female sex workers in Kigali, Rwanda, were analysed cross-sectionally using a phylogenetic microarray specifically designed for the cervicovaginal microbiome. Women with sexually transmitted infections (STIs) were purposefully oversampled. Two hundred fifty one probes were used for co-regularised spectral clustering analysis and 123 probes (specific at species or genus level) to describe the cervicovaginal microbiome clusters. Demographic, behavioral, and clinical correlates of the clusters were also determined.Results. Six cervicovaginal microbiome clusters were identified. Clusters R-I and R-II were dominated by Lactobacillus crispatus and L. iners, respectively, were associated with a Nugent score of 0-3, and had a low (semi-quantitative) bacterial load and diversity. Clusters R-III to R-VI were dominated by Gardnerella vaginalis, Atopobium spp. and Prevotella spp. in different compositions, and were associated with a Nugent score of 7-10; cluster R-V had an intermediate bacterial load and diversity and clusters R-III/R-IV/R-VI had high bacterial loads and diversity. Women in cluster R-I were less likely to have HIV (9% versus 33-57%; p 0.03), herpes simplex virus-2 (36% versus 78-100%; p<0.01), and high risk human papilloma virus (0% versus 38-56%; p<0.01) than the women in the other clusters, and they had no bacterial STIs. Statistically significant trends were found, with the lowest prevalence of STIs in cluster R-I and an increasing prevalence in clusters R-II, R-V, and R-III/ R-IV/ R-VI.Conclusion. In this sample of African sex workers with a high prevalence of HIV and STIs, six cervicovaginal microbiome clusters were identified. Sex workers with a microbiome dominated by L. crispatus (but not L. iners) did not have bacterial STIs and were less likely to have viral STIs than women with other microbiome compositions. Longitudinal studies are needed to determine the temporal relationships between the cervicovaginal microbiome and STIs." @default.
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- W2291787173 date "2013-01-01" @default.
- W2291787173 modified "2023-09-27" @default.
- W2291787173 title "Lactobacillus crispatus-dominated cervicovaginal microbiome associated with fewer sexually transmitted infections in African sex workers" @default.
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