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- W2291837340 abstract "Abstract Six new steroidal glycosides, named stauntosides O-T ( 1 – 6 ), along with eight known compounds ( 7 – 14 ), were obtained from the 95% aqueous ethanol extract of the roots of Cynanchum stauntonii . Their chemical structures were elucidated by IR, HR ESI-MS/MS, 1 H- and 13 C NMR, 1 H- 1 H COSY, HSQC, HSQC-TOCSY, and HMBC spectroscopic analyses, which showed interesting 13,14:14,15-disecopregnane-type or 14,15-secopregnane-type C 21 steroidal glycosides. The glycosides’ anti-inflammatory effects were investigated by detecting the inhibitory effects of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) on RAW246.7 murine macrophage cells stimulated by lipopolysaccharide (LPS). Our results showed that compounds 1 , 5 , 8 , 9 , 11 , and 13 could significantly inhibit iNOS expression, and compounds 5 and 7 could clearly reduce COX-2 expression in RAW246.7 cells stimulated by LPS compared to cells stimulated with LPS and not treated with other compounds. Thus, compounds 1 , 5, 7–9, 11 , and 13 have the potential to mediate anti-inflammatory effects, with compound 5 having a greater anti-inflammatory effect than the other compounds." @default.
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- W2291837340 date "2016-06-01" @default.
- W2291837340 modified "2023-09-25" @default.
- W2291837340 title "Steroidal glycosides from the roots of Cynanchum stauntonii and their effects on the expression of iNOS and COX-2" @default.
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- W2291837340 doi "https://doi.org/10.1016/j.phytol.2016.02.016" @default.
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