Matches in SemOpenAlex for { <https://semopenalex.org/work/W2291925571> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2291925571 abstract "Sildenafil [SIL (Viagra); Pfizer, New York, NY] is a widely prescribed agent for erectile dysfunction in men older than 65 years. The present study evaluated experimental models to assess age-dependent changes in SIL biotransformation using hepatic microsomes from male rats and mice ranging from 6 weeks to 26 months of age. The role of specific isoforms in the conversion of SIL to its primary circulating metabolite, UK-103,320 (piperazine N-desmethyl sildenafil) in the mouse was also investigated using immunoinhibitory antibodies. Although CYP2C11 largely mediated UK-103,320 formation in the rat, UK-103,320 formation was principally inhibited by a CYP3A antibody in the mouse. An age-related decrement in metabolite formation rate was observed for both species, although this effect was more pronounced in the old rats (reduced to 7% of young) than in the old mice (reduced to 51% of young). CYP2C expression was assessed by Western blot analysis in rat and mouse livers. Age-related differences in hepatic CYP3A expression in the mouse were also compared with metabolite formation rates in the mouse model. Decrements with age in CYP2C and -3A expression in the aging rodents paralleled the decrements in SIL biotransformation, suggesting that age-related differences in SIL metabolic rate may, in part, reflect differences in expression. Although the role of specific CYP enzymes and the clearance values for this reaction may differ among species, age-related changes in these rodent models are consistent with the reduced clearance of SIL observed in human studies." @default.
- W2291925571 created "2016-06-24" @default.
- W2291925571 creator A5087737186 @default.
- W2291925571 date "2003-01-01" @default.
- W2291925571 modified "2023-09-23" @default.
- W2291925571 title "Short Communication THE EFFECT OF AGE ON SILDENAFIL BIOTRANSFORMATION IN RAT AND MOUSE LIVER MICROSOMES" @default.
- W2291925571 cites W1484324193 @default.
- W2291925571 cites W1746765074 @default.
- W2291925571 cites W1855544903 @default.
- W2291925571 cites W1900638780 @default.
- W2291925571 cites W1956875558 @default.
- W2291925571 cites W1982281684 @default.
- W2291925571 cites W2022628424 @default.
- W2291925571 cites W2027202120 @default.
- W2291925571 cites W2042436634 @default.
- W2291925571 cites W2066312456 @default.
- W2291925571 cites W2072370066 @default.
- W2291925571 cites W2087082360 @default.
- W2291925571 cites W2099679633 @default.
- W2291925571 cites W2130559063 @default.
- W2291925571 cites W2140892681 @default.
- W2291925571 cites W2146841174 @default.
- W2291925571 cites W2147652734 @default.
- W2291925571 cites W2163919962 @default.
- W2291925571 cites W2166929201 @default.
- W2291925571 cites W2297358297 @default.
- W2291925571 cites W2435483981 @default.
- W2291925571 cites W2979021191 @default.
- W2291925571 hasPublicationYear "2003" @default.
- W2291925571 type Work @default.
- W2291925571 sameAs 2291925571 @default.
- W2291925571 citedByCount "0" @default.
- W2291925571 crossrefType "journal-article" @default.
- W2291925571 hasAuthorship W2291925571A5087737186 @default.
- W2291925571 hasConcept C104317684 @default.
- W2291925571 hasConcept C11824378 @default.
- W2291925571 hasConcept C126322002 @default.
- W2291925571 hasConcept C134018914 @default.
- W2291925571 hasConcept C181199279 @default.
- W2291925571 hasConcept C2776415932 @default.
- W2291925571 hasConcept C2777477808 @default.
- W2291925571 hasConcept C27881333 @default.
- W2291925571 hasConcept C526171541 @default.
- W2291925571 hasConcept C55493867 @default.
- W2291925571 hasConcept C62231903 @default.
- W2291925571 hasConcept C71924100 @default.
- W2291925571 hasConcept C86803240 @default.
- W2291925571 hasConcept C87644729 @default.
- W2291925571 hasConcept C98274493 @default.
- W2291925571 hasConceptScore W2291925571C104317684 @default.
- W2291925571 hasConceptScore W2291925571C11824378 @default.
- W2291925571 hasConceptScore W2291925571C126322002 @default.
- W2291925571 hasConceptScore W2291925571C134018914 @default.
- W2291925571 hasConceptScore W2291925571C181199279 @default.
- W2291925571 hasConceptScore W2291925571C2776415932 @default.
- W2291925571 hasConceptScore W2291925571C2777477808 @default.
- W2291925571 hasConceptScore W2291925571C27881333 @default.
- W2291925571 hasConceptScore W2291925571C526171541 @default.
- W2291925571 hasConceptScore W2291925571C55493867 @default.
- W2291925571 hasConceptScore W2291925571C62231903 @default.
- W2291925571 hasConceptScore W2291925571C71924100 @default.
- W2291925571 hasConceptScore W2291925571C86803240 @default.
- W2291925571 hasConceptScore W2291925571C87644729 @default.
- W2291925571 hasConceptScore W2291925571C98274493 @default.
- W2291925571 hasLocation W22919255711 @default.
- W2291925571 hasOpenAccess W2291925571 @default.
- W2291925571 hasPrimaryLocation W22919255711 @default.
- W2291925571 hasRelatedWork W1978776663 @default.
- W2291925571 hasRelatedWork W1982976588 @default.
- W2291925571 hasRelatedWork W1984139042 @default.
- W2291925571 hasRelatedWork W1993489943 @default.
- W2291925571 hasRelatedWork W2045857514 @default.
- W2291925571 hasRelatedWork W2058192470 @default.
- W2291925571 hasRelatedWork W2076588073 @default.
- W2291925571 hasRelatedWork W2079043903 @default.
- W2291925571 hasRelatedWork W2091369607 @default.
- W2291925571 hasRelatedWork W2100791192 @default.
- W2291925571 hasRelatedWork W2122507578 @default.
- W2291925571 hasRelatedWork W2141873233 @default.
- W2291925571 hasRelatedWork W2163165092 @default.
- W2291925571 hasRelatedWork W2281497012 @default.
- W2291925571 hasRelatedWork W2406560526 @default.
- W2291925571 hasRelatedWork W2465914089 @default.
- W2291925571 hasRelatedWork W2884894137 @default.
- W2291925571 hasRelatedWork W3108731813 @default.
- W2291925571 hasRelatedWork W2130020444 @default.
- W2291925571 hasRelatedWork W2340413496 @default.
- W2291925571 isParatext "false" @default.
- W2291925571 isRetracted "false" @default.
- W2291925571 magId "2291925571" @default.
- W2291925571 workType "article" @default.