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- W2291931403 endingPage "3083" @default.
- W2291931403 startingPage "3078" @default.
- W2291931403 abstract "Significance In humans and genetically engineered mouse models (GEMs), the development of pancreatic ductal adenocarcinoma (PDAC) is accompanied by intimate neural–tumor interactions. Using a PDAC GEM that phenocopies the human disease, we found that many changes in peripheral and central nervous systems, indicative of injury and inflammation, arise at time points prior to overt tumor formation. Ablation of sensory neurons that innervate the pancreas, via neonatal capsaicin treatment, prevented neurogenic inflammation and delayed tumor formation. The slowing of PDAC in capsaicin-treated mice suggests the nervous system is not a bystander with respect to disease progression. Further studies are warranted to examine nervous system–tumor interactions and to identify potential targets for early detection, prevention, and treatment." @default.
- W2291931403 created "2016-06-24" @default.
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- W2291931403 date "2016-02-29" @default.
- W2291931403 modified "2023-10-15" @default.
- W2291931403 title "Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer" @default.
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- W2291931403 doi "https://doi.org/10.1073/pnas.1512603113" @default.
- W2291931403 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4801275" @default.
- W2291931403 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26929329" @default.
- W2291931403 hasPublicationYear "2016" @default.