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W2291942102 abstract "Betatricalcium phosphate (β-TCP), nano-alumina- and nano-alumina/nano-silica – added β-TCP scaffolds were prepared by the foam replication method followed by sintering at 1200–1300 °C. The rheological properties of β-TCP and the nano-additive-containing β-TCP slurries were investigated using a computerized rheometer. The phase composition, mechanical strength, microstructure and rat-calvarium-derived osteoblast responses of the scaffolds were also studied. The results showed that nano-alumina decreased viscosity of β-TCP slurry and receded its thixotropy whereas a reverse result was obtained for the nano-silica additive. The phase composition of the scaffolds was whitlockite regardless of sintering temperature. The nano-alumina-added β-TCP scaffolds were 2–4 times stronger than pure β-TCP and their compressive strength values were in the range of 0.1–0.5 MPa, depending on the additive content and temperature. However, when nano-alumina and nano-silica were simultaneously used, the compressive strength was dramatically improved to 5 MPa for temperature 1250 °C and 15 MPa for temperature 1300 °C. Adding nano-alumina and nano-alumina/nano-silica to pure β-TCP resulted in a more compacted microstructure with reduced grain size. All scaffolds exhibited adequate cell attachment, but the proliferation and alkaline phosphatase activity of the cells increased when nano-alumina and nano-silica were simultaneously used. Overall, tissue engineering scaffolds with interconnected macropores and improved mechanical and biological properties can be fabricated using a small quantity of nano-alumina and nano-silica additives." @default.
W2291942102 created "2016-06-24" @default.
W2291942102 creator A5081200340 @default.
W2291942102 date "2016-05-01" @default.
W2291942102 modified "2023-09-28" @default.
W2291942102 title "Feasibility of alumina and alumina-silica nanoparticles to fabricate strengthened betatricalcium phosphate scaffold with improved biological responses" @default.
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W2291942102 doi "https://doi.org/10.1016/j.ceramint.2016.01.167" @default.
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