Matches in SemOpenAlex for { <https://semopenalex.org/work/W2291943310> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2291943310 endingPage "629" @default.
- W2291943310 startingPage "623" @default.
- W2291943310 abstract "Mononuclear inflammatory cells were retrospectively analysed using monoclonal antibodies in the interstitium and glomeruli of 16 renal biopsy specimens from patients with nephrotic syndrome due to idiopathic membranous nephropathy (IMN). The aim of the study was to determine the composition of the infiltrate and to assess the ability to predict the response of proteinuria to corticosteroids. All patients had received prednisolone as a sole treatment. Nine patients had shown a complete or partial remission of proteinuria (group A) and seven did not respond at all (group B). Both groups were matched for age and degree of proteinuria; also both groups had normal renal function at the time of biopsy. Very few intraglomerular leukocytes, mostly monocytes/macrophages (MM) were found. The majority of interstitial T cell population and B cells were a minor component. No significant differences were found between the two groups regarding the types of the intraglomerular cells. However, interstitial T-cells, CD4+ve T helper/inducer cells, CD8+ve T cytotoxic/suppressor cells and MM were significantly higher in group A than in group B. Also HLA-DR expressing interstitial cells were much in excess in group A. In addition patients with complete remission of proteinuria had higher numbers of interstitial cells compared to those with partial response. There was no correlation between the numbers of types of intraglomerular and interstitial cells and the degree of proteinuria at presentation. Also no association was found between intraglomerular or interstitial cell population and subsequent relapse of proteinuria. In conclusion, interstitial but not intraglomerular mononuclear cells seem to determine the initial response of proteinuria to corticosteroids in patients with IMN." @default.
- W2291943310 created "2016-06-24" @default.
- W2291943310 creator A5015600805 @default.
- W2291943310 creator A5021490804 @default.
- W2291943310 creator A5060698199 @default.
- W2291943310 date "1994-01-01" @default.
- W2291943310 modified "2023-09-27" @default.
- W2291943310 title "Relationship between interstitial infiltrates and steroid responsiveness of proteinuria in membranous nephropathy" @default.
- W2291943310 doi "https://doi.org/10.1093/ndt/9.6.623" @default.
- W2291943310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7970087" @default.
- W2291943310 hasPublicationYear "1994" @default.
- W2291943310 type Work @default.
- W2291943310 sameAs 2291943310 @default.
- W2291943310 citedByCount "16" @default.
- W2291943310 crossrefType "journal-article" @default.
- W2291943310 hasAuthorship W2291943310A5015600805 @default.
- W2291943310 hasAuthorship W2291943310A5021490804 @default.
- W2291943310 hasAuthorship W2291943310A5060698199 @default.
- W2291943310 hasConcept C126322002 @default.
- W2291943310 hasConcept C137061746 @default.
- W2291943310 hasConcept C142724271 @default.
- W2291943310 hasConcept C147483822 @default.
- W2291943310 hasConcept C167672396 @default.
- W2291943310 hasConcept C202751555 @default.
- W2291943310 hasConcept C203014093 @default.
- W2291943310 hasConcept C2775934546 @default.
- W2291943310 hasConcept C2775946357 @default.
- W2291943310 hasConcept C2776090121 @default.
- W2291943310 hasConcept C2778930706 @default.
- W2291943310 hasConcept C2779561371 @default.
- W2291943310 hasConcept C2780091579 @default.
- W2291943310 hasConcept C2780368995 @default.
- W2291943310 hasConcept C2781087799 @default.
- W2291943310 hasConcept C2908647359 @default.
- W2291943310 hasConcept C55493867 @default.
- W2291943310 hasConcept C71924100 @default.
- W2291943310 hasConcept C86803240 @default.
- W2291943310 hasConcept C8891405 @default.
- W2291943310 hasConcept C99454951 @default.
- W2291943310 hasConceptScore W2291943310C126322002 @default.
- W2291943310 hasConceptScore W2291943310C137061746 @default.
- W2291943310 hasConceptScore W2291943310C142724271 @default.
- W2291943310 hasConceptScore W2291943310C147483822 @default.
- W2291943310 hasConceptScore W2291943310C167672396 @default.
- W2291943310 hasConceptScore W2291943310C202751555 @default.
- W2291943310 hasConceptScore W2291943310C203014093 @default.
- W2291943310 hasConceptScore W2291943310C2775934546 @default.
- W2291943310 hasConceptScore W2291943310C2775946357 @default.
- W2291943310 hasConceptScore W2291943310C2776090121 @default.
- W2291943310 hasConceptScore W2291943310C2778930706 @default.
- W2291943310 hasConceptScore W2291943310C2779561371 @default.
- W2291943310 hasConceptScore W2291943310C2780091579 @default.
- W2291943310 hasConceptScore W2291943310C2780368995 @default.
- W2291943310 hasConceptScore W2291943310C2781087799 @default.
- W2291943310 hasConceptScore W2291943310C2908647359 @default.
- W2291943310 hasConceptScore W2291943310C55493867 @default.
- W2291943310 hasConceptScore W2291943310C71924100 @default.
- W2291943310 hasConceptScore W2291943310C86803240 @default.
- W2291943310 hasConceptScore W2291943310C8891405 @default.
- W2291943310 hasConceptScore W2291943310C99454951 @default.
- W2291943310 hasIssue "6" @default.
- W2291943310 hasLocation W22919433101 @default.
- W2291943310 hasLocation W22919433102 @default.
- W2291943310 hasOpenAccess W2291943310 @default.
- W2291943310 hasPrimaryLocation W22919433101 @default.
- W2291943310 hasRelatedWork W2021240551 @default.
- W2291943310 hasRelatedWork W2044941027 @default.
- W2291943310 hasRelatedWork W2082173970 @default.
- W2291943310 hasRelatedWork W2091143903 @default.
- W2291943310 hasRelatedWork W2255097837 @default.
- W2291943310 hasRelatedWork W2475017726 @default.
- W2291943310 hasRelatedWork W3134059829 @default.
- W2291943310 hasRelatedWork W4296373815 @default.
- W2291943310 hasRelatedWork W4300513650 @default.
- W2291943310 hasRelatedWork W90396326 @default.
- W2291943310 hasVolume "9" @default.
- W2291943310 isParatext "false" @default.
- W2291943310 isRetracted "false" @default.
- W2291943310 magId "2291943310" @default.
- W2291943310 workType "article" @default.