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- W2291986711 endingPage "1713" @default.
- W2291986711 startingPage "1700" @default.
- W2291986711 abstract "Autophagy is a fundamental cellular mechanism responsible for bulk turnover of cytoplasmic components. It is broadly related to many cellular activities, physiological processes, and pathological conditions. Autophagy entails a spatiotemporal interaction between cytosolic factors and membranes that are remodeled to encapsulate autophagic cargo within an autophagosome. Although majority of the factors [autophagy-related gene (Atg) proteins] involved in autophagy have been identified by genetic studies, the mechanism accounting for how these factors act upon the membrane to remodel it and efficiently recruit cargo for degradation is unclear. In vitro reconstitution of several different aspects of autophagy has provided important insights into the understanding of the mechanistic details underlying autophagic membrane remodeling and cargo recruitment. Here, we highlight these efforts toward studying autophagy through in vitro approaches." @default.
- W2291986711 created "2016-06-24" @default.
- W2291986711 creator A5053204257 @default.
- W2291986711 creator A5078387030 @default.
- W2291986711 creator A5084548935 @default.
- W2291986711 date "2016-05-01" @default.
- W2291986711 modified "2023-09-23" @default.
- W2291986711 title "Mechanistically Dissecting Autophagy: Insights from In Vitro Reconstitution" @default.
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