Matches in SemOpenAlex for { <https://semopenalex.org/work/W2291998788> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2291998788 abstract "Interactions of peptides with membranes are central for understanding key cellular processes involving membrane proteins such as folding, signaling, transport, energy conversion, and immune response. These interactions also determine efficiency of antibacterial and cytotoxic peptides in disrupting the barrier function of cellular membranes. We employed macroscopically aligned tubular lipid bilayers confined inside cylindrical nanopores of anodic aluminum oxide (AAO) as a versatile nanotechnology platform to study membrane interactions of antibacterial peptides of melittin and alamecitin. Kinetics of peptide binding to lipid nanotubes and the eventual lipid removal/lysis (for melittin) were observed by quartz crystal microbalance (QCM) using a crystal with an in-house fabricated nanostructured surface while the structural changes in bilayers were monitored by solid state oriented sample NMR. Specifically, using 78 nm nanopores we have achieved exceptionally narrow (100-140 Hz or <1 ppm) 31P resonances of the lipid phosphate groups of macroscopically aligned nanotubular bilayers that indicated <1-2o mosaic spread in the lipid alignment in the absence of bioreactive peptides. 31P resonances broadened and shifted towards the isotropic values upon interacting with melittin with some lysis of lipids observed after several hours of exposure. The binding and lipid lysis from bilayers confined in essentially the same nanopores albeit at much smaller lipid quantity were further quantified by real-time QCM for bilayers of various lipid compositions. Taken together, the data relate peptide binding and lysis kinetics to structural changes in lipid bilayers, thus, shedding the light on the underlying multistep mechanism. The main advantage of the lipid nanotube AAO platform is in its versatile applicability to various biophysical methods such QCM and NMR under essentially the same environmental conditions such as pH, ionic strength, temperature, etc. and exceptionally broad range of lipid bilayer compositions." @default.
- W2291998788 created "2016-06-24" @default.
- W2291998788 creator A5010436713 @default.
- W2291998788 creator A5018118586 @default.
- W2291998788 creator A5028577982 @default.
- W2291998788 creator A5048795375 @default.
- W2291998788 creator A5070993328 @default.
- W2291998788 creator A5083406442 @default.
- W2291998788 creator A5089280955 @default.
- W2291998788 date "2016-02-01" @default.
- W2291998788 modified "2023-09-29" @default.
- W2291998788 title "Interactions of Antibacterial Peptides with Nanotubular Lipid Bilayers: Binding Kinetics and Distortions of the Bilayer Structure" @default.
- W2291998788 doi "https://doi.org/10.1016/j.bpj.2015.11.488" @default.
- W2291998788 hasPublicationYear "2016" @default.
- W2291998788 type Work @default.
- W2291998788 sameAs 2291998788 @default.
- W2291998788 citedByCount "0" @default.
- W2291998788 crossrefType "journal-article" @default.
- W2291998788 hasAuthorship W2291998788A5010436713 @default.
- W2291998788 hasAuthorship W2291998788A5018118586 @default.
- W2291998788 hasAuthorship W2291998788A5028577982 @default.
- W2291998788 hasAuthorship W2291998788A5048795375 @default.
- W2291998788 hasAuthorship W2291998788A5070993328 @default.
- W2291998788 hasAuthorship W2291998788A5083406442 @default.
- W2291998788 hasAuthorship W2291998788A5089280955 @default.
- W2291998788 hasBestOaLocation W22919987881 @default.
- W2291998788 hasConcept C121332964 @default.
- W2291998788 hasConcept C12554922 @default.
- W2291998788 hasConcept C130316041 @default.
- W2291998788 hasConcept C141795571 @default.
- W2291998788 hasConcept C148898269 @default.
- W2291998788 hasConcept C150394285 @default.
- W2291998788 hasConcept C152900378 @default.
- W2291998788 hasConcept C170493617 @default.
- W2291998788 hasConcept C171250308 @default.
- W2291998788 hasConcept C178790620 @default.
- W2291998788 hasConcept C185592680 @default.
- W2291998788 hasConcept C192157962 @default.
- W2291998788 hasConcept C192562407 @default.
- W2291998788 hasConcept C2778001312 @default.
- W2291998788 hasConcept C2779281246 @default.
- W2291998788 hasConcept C39944091 @default.
- W2291998788 hasConcept C41625074 @default.
- W2291998788 hasConcept C55493867 @default.
- W2291998788 hasConcept C57409179 @default.
- W2291998788 hasConcept C62520636 @default.
- W2291998788 hasConcept C8010536 @default.
- W2291998788 hasConcept C86803240 @default.
- W2291998788 hasConcept C9996572 @default.
- W2291998788 hasConceptScore W2291998788C121332964 @default.
- W2291998788 hasConceptScore W2291998788C12554922 @default.
- W2291998788 hasConceptScore W2291998788C130316041 @default.
- W2291998788 hasConceptScore W2291998788C141795571 @default.
- W2291998788 hasConceptScore W2291998788C148898269 @default.
- W2291998788 hasConceptScore W2291998788C150394285 @default.
- W2291998788 hasConceptScore W2291998788C152900378 @default.
- W2291998788 hasConceptScore W2291998788C170493617 @default.
- W2291998788 hasConceptScore W2291998788C171250308 @default.
- W2291998788 hasConceptScore W2291998788C178790620 @default.
- W2291998788 hasConceptScore W2291998788C185592680 @default.
- W2291998788 hasConceptScore W2291998788C192157962 @default.
- W2291998788 hasConceptScore W2291998788C192562407 @default.
- W2291998788 hasConceptScore W2291998788C2778001312 @default.
- W2291998788 hasConceptScore W2291998788C2779281246 @default.
- W2291998788 hasConceptScore W2291998788C39944091 @default.
- W2291998788 hasConceptScore W2291998788C41625074 @default.
- W2291998788 hasConceptScore W2291998788C55493867 @default.
- W2291998788 hasConceptScore W2291998788C57409179 @default.
- W2291998788 hasConceptScore W2291998788C62520636 @default.
- W2291998788 hasConceptScore W2291998788C8010536 @default.
- W2291998788 hasConceptScore W2291998788C86803240 @default.
- W2291998788 hasConceptScore W2291998788C9996572 @default.
- W2291998788 hasLocation W22919987881 @default.
- W2291998788 hasOpenAccess W2291998788 @default.
- W2291998788 hasPrimaryLocation W22919987881 @default.
- W2291998788 hasRelatedWork W1923374206 @default.
- W2291998788 hasRelatedWork W1999877742 @default.
- W2291998788 hasRelatedWork W2006259064 @default.
- W2291998788 hasRelatedWork W2015644245 @default.
- W2291998788 hasRelatedWork W2027744830 @default.
- W2291998788 hasRelatedWork W2074623702 @default.
- W2291998788 hasRelatedWork W2116452439 @default.
- W2291998788 hasRelatedWork W2137827816 @default.
- W2291998788 hasRelatedWork W2184049420 @default.
- W2291998788 hasRelatedWork W2556792563 @default.
- W2291998788 hasRelatedWork W2583284217 @default.
- W2291998788 hasRelatedWork W2621338256 @default.
- W2291998788 hasRelatedWork W2747365677 @default.
- W2291998788 hasRelatedWork W2786051729 @default.
- W2291998788 hasRelatedWork W2789928417 @default.
- W2291998788 hasRelatedWork W2894838646 @default.
- W2291998788 hasRelatedWork W2990909085 @default.
- W2291998788 hasRelatedWork W423705547 @default.
- W2291998788 hasRelatedWork W42890019 @default.
- W2291998788 hasRelatedWork W599436093 @default.
- W2291998788 isParatext "false" @default.
- W2291998788 isRetracted "false" @default.
- W2291998788 magId "2291998788" @default.
- W2291998788 workType "article" @default.