Matches in SemOpenAlex for { <https://semopenalex.org/work/W2292019977> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2292019977 abstract "Conventional bone morphogenetic protein 2 (Bmp2) is a secreted growth factor characterized by its ability to induce bone and cartilage formation, and by its role in developmental processes such as axis formation, cardiac development, and neuronal differentiation. Recently, however, we have identified a novel form of Bmp2 (nBmp2) that is translated from an alternative start codon and is localized to the nucleus rather than being secreted. To study the function of nBmp2 in the nucleus, we generated mice bearing an nBmp2 mutation that prevents nuclear localization. Here we evaluate muscle performance in these mutant mice using in situ stimulation of the gastrocnemius, plantaris, soleus (GPS) muscle complex via the sciatic nerve. Specific peak tetanic force of the GPS muscle group was slightly higher in nBmp2 deficient mice compared to control mice (3.3 ± 0.1 and 3.1 ± 0.1 gm tension/mg muscle in mutant vs. control muscles, respectively, p>0.05). No significant differences were observed in the specific peak twitch force between groups. Muscle fatigue was examined using 2Hz twitch contractions for 10 min. The fatigue profiles for the two groups were essentially identical, but half relaxation times were significantly prolonged by up to a 42% increase in mutant muscles compared to control muscles (p<0.05). Further, force frequency analysis showed significantly elevated force production in mutant muscles compared to controls from 10 to 80 Hz stimulation frequency (p<0.01). These results suggest that nBmp2 plays an important role in maintaining normal intracellular transport of calcium during skeletal muscle contraction and relaxation. Grant support: NIH AR48839" @default.
- W2292019977 created "2016-06-24" @default.
- W2292019977 creator A5007925318 @default.
- W2292019977 creator A5011916249 @default.
- W2292019977 creator A5040214380 @default.
- W2292019977 creator A5055265343 @default.
- W2292019977 creator A5088784322 @default.
- W2292019977 date "2010-04-01" @default.
- W2292019977 modified "2023-09-27" @default.
- W2292019977 title "Nuclear bone morphogenetic protein 2 mutant mice exhibit slowed relaxation and a shift in the force frequency relationship in skeletal muscle" @default.
- W2292019977 doi "https://doi.org/10.1096/fasebj.24.1_supplement.lb676" @default.
- W2292019977 hasPublicationYear "2010" @default.
- W2292019977 type Work @default.
- W2292019977 sameAs 2292019977 @default.
- W2292019977 citedByCount "0" @default.
- W2292019977 crossrefType "journal-article" @default.
- W2292019977 hasAuthorship W2292019977A5007925318 @default.
- W2292019977 hasAuthorship W2292019977A5011916249 @default.
- W2292019977 hasAuthorship W2292019977A5040214380 @default.
- W2292019977 hasAuthorship W2292019977A5055265343 @default.
- W2292019977 hasAuthorship W2292019977A5088784322 @default.
- W2292019977 hasConcept C105702510 @default.
- W2292019977 hasConcept C126322002 @default.
- W2292019977 hasConcept C134018914 @default.
- W2292019977 hasConcept C163415756 @default.
- W2292019977 hasConcept C185592680 @default.
- W2292019977 hasConcept C202751555 @default.
- W2292019977 hasConcept C24998067 @default.
- W2292019977 hasConcept C2776104385 @default.
- W2292019977 hasConcept C2779959927 @default.
- W2292019977 hasConcept C2780723820 @default.
- W2292019977 hasConcept C30352789 @default.
- W2292019977 hasConcept C55493867 @default.
- W2292019977 hasConcept C71924100 @default.
- W2292019977 hasConcept C86803240 @default.
- W2292019977 hasConcept C95444343 @default.
- W2292019977 hasConceptScore W2292019977C105702510 @default.
- W2292019977 hasConceptScore W2292019977C126322002 @default.
- W2292019977 hasConceptScore W2292019977C134018914 @default.
- W2292019977 hasConceptScore W2292019977C163415756 @default.
- W2292019977 hasConceptScore W2292019977C185592680 @default.
- W2292019977 hasConceptScore W2292019977C202751555 @default.
- W2292019977 hasConceptScore W2292019977C24998067 @default.
- W2292019977 hasConceptScore W2292019977C2776104385 @default.
- W2292019977 hasConceptScore W2292019977C2779959927 @default.
- W2292019977 hasConceptScore W2292019977C2780723820 @default.
- W2292019977 hasConceptScore W2292019977C30352789 @default.
- W2292019977 hasConceptScore W2292019977C55493867 @default.
- W2292019977 hasConceptScore W2292019977C71924100 @default.
- W2292019977 hasConceptScore W2292019977C86803240 @default.
- W2292019977 hasConceptScore W2292019977C95444343 @default.
- W2292019977 hasFunder F4320332161 @default.
- W2292019977 hasIssue "S1" @default.
- W2292019977 hasLocation W22920199771 @default.
- W2292019977 hasOpenAccess W2292019977 @default.
- W2292019977 hasPrimaryLocation W22920199771 @default.
- W2292019977 hasRelatedWork W1966223210 @default.
- W2292019977 hasRelatedWork W2007330211 @default.
- W2292019977 hasRelatedWork W2016264464 @default.
- W2292019977 hasRelatedWork W2054992011 @default.
- W2292019977 hasRelatedWork W2058153407 @default.
- W2292019977 hasRelatedWork W2064416809 @default.
- W2292019977 hasRelatedWork W2309978229 @default.
- W2292019977 hasRelatedWork W2320681237 @default.
- W2292019977 hasRelatedWork W2463478234 @default.
- W2292019977 hasRelatedWork W2893460394 @default.
- W2292019977 hasVolume "24" @default.
- W2292019977 isParatext "false" @default.
- W2292019977 isRetracted "false" @default.
- W2292019977 magId "2292019977" @default.
- W2292019977 workType "article" @default.