Matches in SemOpenAlex for { <https://semopenalex.org/work/W2292042593> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2292042593 endingPage "36" @default.
- W2292042593 startingPage "31" @default.
- W2292042593 abstract "The purpose of this study was to investigate the effect of non ionic surfactant on the mechanical properties of acetaminophen-wax matrix tablet and hence its implication on dissolution profile. Acetaminophen-wax matrix granules were prepared by melt granulation technique. This was formed by triturating acetaminophen powder (100g) with melted carnauba wax (20g), and with varying concentrations of polysorbate 80 or sorbitan monooleate (0-10%w/w) The molten mass was screened through sieves and air dried, hence drug to wax ratio was 5:1. The matrix tablets were formed by compressing the wax matrix granules at a constant load (30 arbitrary units on the load scale). The tablets were evaluated for tablet tensile strength, packing fraction, friability and in vitro dissolution profile. The dissolution data were analysed with different mathematical models namely zero order flux, first order, Higuchi, and Korsmeyer and Peppas equations in order to confirm the mechanism of drug release. All the tablets irrespective of concentration or type of surfactant used were compressible with tensile strength and packing fraction values between 1.47 to 1.63NMm -2 and 0.96 and 0.98 respectively. Their friability values were = 0.34%. The release rate increased with increase in concentrations of the non-ionic surfactants attributable to enhanced wetting of the solid dosage form by the presence of the surfactant. The analysed dissolution data revealed that the drug release fit first order flux and Higuchi square root of time model evident by their high correlation coefficient (r =0.93). The indication is that the drug release from these matrix tablets is by diffusion-controlled process. The mechanism of drug release was by anomalous (non-Fickian) diffusion indicated by their n values between 0.45 and 0.89. The study has shown that presence of non- ionic surfactants at an optimised concentration can be used to modulate the release of drug from wax matrix tablets. Keywords: Wax Matrix Tablets, Non-ionic Surfactants, Tensile Strength, Dissolution Profile, First Order Flux and Higuchi Square Root of Time Model." @default.
- W2292042593 created "2016-06-24" @default.
- W2292042593 creator A5019825956 @default.
- W2292042593 creator A5042007015 @default.
- W2292042593 creator A5060458334 @default.
- W2292042593 date "2012-01-01" @default.
- W2292042593 modified "2023-09-24" @default.
- W2292042593 title "Effect of surfactants on the mechanical properties of acetaminophen - wax matrix tablets and its implication on dissolution profile" @default.
- W2292042593 cites W1511449683 @default.
- W2292042593 cites W1580138291 @default.
- W2292042593 cites W1977072597 @default.
- W2292042593 cites W2023571229 @default.
- W2292042593 cites W2086130473 @default.
- W2292042593 cites W2443190980 @default.
- W2292042593 cites W85616151 @default.
- W2292042593 cites W2428932408 @default.
- W2292042593 cites W2944988524 @default.
- W2292042593 hasPublicationYear "2012" @default.
- W2292042593 type Work @default.
- W2292042593 sameAs 2292042593 @default.
- W2292042593 citedByCount "0" @default.
- W2292042593 crossrefType "journal-article" @default.
- W2292042593 hasAuthorship W2292042593A5019825956 @default.
- W2292042593 hasAuthorship W2292042593A5042007015 @default.
- W2292042593 hasAuthorship W2292042593A5060458334 @default.
- W2292042593 hasConcept C106487976 @default.
- W2292042593 hasConcept C112950240 @default.
- W2292042593 hasConcept C127413603 @default.
- W2292042593 hasConcept C153033020 @default.
- W2292042593 hasConcept C159985019 @default.
- W2292042593 hasConcept C178790620 @default.
- W2292042593 hasConcept C184651966 @default.
- W2292042593 hasConcept C185592680 @default.
- W2292042593 hasConcept C187428577 @default.
- W2292042593 hasConcept C191168616 @default.
- W2292042593 hasConcept C192562407 @default.
- W2292042593 hasConcept C2776035855 @default.
- W2292042593 hasConcept C2780039118 @default.
- W2292042593 hasConcept C42360764 @default.
- W2292042593 hasConcept C43617362 @default.
- W2292042593 hasConcept C521977710 @default.
- W2292042593 hasConcept C55493867 @default.
- W2292042593 hasConcept C58226133 @default.
- W2292042593 hasConcept C88380143 @default.
- W2292042593 hasConcept C88463166 @default.
- W2292042593 hasConceptScore W2292042593C106487976 @default.
- W2292042593 hasConceptScore W2292042593C112950240 @default.
- W2292042593 hasConceptScore W2292042593C127413603 @default.
- W2292042593 hasConceptScore W2292042593C153033020 @default.
- W2292042593 hasConceptScore W2292042593C159985019 @default.
- W2292042593 hasConceptScore W2292042593C178790620 @default.
- W2292042593 hasConceptScore W2292042593C184651966 @default.
- W2292042593 hasConceptScore W2292042593C185592680 @default.
- W2292042593 hasConceptScore W2292042593C187428577 @default.
- W2292042593 hasConceptScore W2292042593C191168616 @default.
- W2292042593 hasConceptScore W2292042593C192562407 @default.
- W2292042593 hasConceptScore W2292042593C2776035855 @default.
- W2292042593 hasConceptScore W2292042593C2780039118 @default.
- W2292042593 hasConceptScore W2292042593C42360764 @default.
- W2292042593 hasConceptScore W2292042593C43617362 @default.
- W2292042593 hasConceptScore W2292042593C521977710 @default.
- W2292042593 hasConceptScore W2292042593C55493867 @default.
- W2292042593 hasConceptScore W2292042593C58226133 @default.
- W2292042593 hasConceptScore W2292042593C88380143 @default.
- W2292042593 hasConceptScore W2292042593C88463166 @default.
- W2292042593 hasIssue "1" @default.
- W2292042593 hasLocation W22920425931 @default.
- W2292042593 hasOpenAccess W2292042593 @default.
- W2292042593 hasPrimaryLocation W22920425931 @default.
- W2292042593 hasRelatedWork W2034097416 @default.
- W2292042593 hasRelatedWork W2044777167 @default.
- W2292042593 hasRelatedWork W2059561640 @default.
- W2292042593 hasRelatedWork W2065823069 @default.
- W2292042593 hasRelatedWork W2145031997 @default.
- W2292042593 hasRelatedWork W2185759073 @default.
- W2292042593 hasRelatedWork W2322485501 @default.
- W2292042593 hasRelatedWork W2325793118 @default.
- W2292042593 hasRelatedWork W2428091179 @default.
- W2292042593 hasRelatedWork W2553309453 @default.
- W2292042593 hasRelatedWork W2605789500 @default.
- W2292042593 hasRelatedWork W2807272340 @default.
- W2292042593 hasRelatedWork W3042153741 @default.
- W2292042593 hasRelatedWork W3088381215 @default.
- W2292042593 hasRelatedWork W3166748938 @default.
- W2292042593 hasRelatedWork W3174767622 @default.
- W2292042593 hasRelatedWork W2132926769 @default.
- W2292042593 hasRelatedWork W2183601082 @default.
- W2292042593 hasRelatedWork W2188569339 @default.
- W2292042593 hasRelatedWork W2428932408 @default.
- W2292042593 hasVolume "14" @default.
- W2292042593 isParatext "false" @default.
- W2292042593 isRetracted "false" @default.
- W2292042593 magId "2292042593" @default.
- W2292042593 workType "article" @default.