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- W2292052562 abstract "The ubiquitin proteasome, the major proteolytic nanomachine in skeletal muscle, is influenced by energy state and endocrine environment. No studies have examined the effect of an acute energy deficit on proteasome activity in humans. PURPOSE This study assessed the effect of an acute energy deficit on 26S proteasome activity at rest and following endurance exercise in physically active adults. METHODS Men (n=11) and women (n=7) participated in a 20d, two-phase diet intervention: weight maintenance, WM; and energy deficient, ~80% of energy requirements, ED. Dietary protein (1.5 g·kg−1·d−1) and fat (~30% of total calories) were constant for WM and ED. 26S activity was measured, using a fluorescence-based assay, following exercise (45min run, 65% VO2peak) and at rest for WM and ED diet interventions. Plasma insulin levels were determined by ELISA. RESULTS 26S activity increased by 24% (P < 0.05) for ED versus WM post-exercise. Insulin was lower (P < 0.05) for ED (14 ± 1 μIU/mL) compared to WM (19 ± 2 μIU/mL). The reduction in insulin was inversely correlated to 26S activity (r=0.55, P < 0.01). CONCLUSIONS These findings suggest that ubiquitin proteasome activity was upregulated in response to an acute, moderate energy deficit that is potentiated following a bout of endurance exercise. Further research is warranted to investigate the effects of energy homeostasis on the regulation of skeletal muscle proteolysis." @default.
- W2292052562 created "2016-06-24" @default.
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- W2292052562 date "2009-04-01" @default.
- W2292052562 modified "2023-10-16" @default.
- W2292052562 title "Moderate energy deprivation increases ubiquitin proteasome activity in physically active adults following endurance exercise" @default.
- W2292052562 doi "https://doi.org/10.1096/fasebj.23.1_supplement.720.1" @default.
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