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- W2292054199 abstract "The scientific literature concerning Chinese hamster ovary (CHO) cells grows annually due to the importance of CHO cells in industrial bioprocessing of therapeutics. In an effort to start to catalogue the breadth of CHO phenotypes, or phenome, we present the CHO bibliome. This bibliographic compilation covers all published CHO cell studies from 1995 to 2015, and each study is classified by the types of phenotypic and bioprocess data contained therein. Using data from selected studies, we also present a quantitative meta-analysis of bioprocess characteristics across diverse culture conditions, yielding novel insights and addressing the validity of long held assumptions. Specifically, we show that bioprocess titers can be predicted using indicator variables derived from viable cell density, viability, and culture duration. We further identified a positive correlation between the cumulative viable cell density (VCD) and final titer, irrespective of cell line, media, and other bioprocess parameters. In addition, growth rate was negatively correlated with performance attributes, such as VCD and titer. In summary, despite assumptions that technical diversity among studies and opaque publication practices can limit research re-use in this field, we show that the statistical analysis of diverse legacy bioprocess data can provide insight into bioprocessing capabilities of CHO cell lines used in industry. The CHO bibliome can be accessed at http://lewislab.ucsd.edu/cho-bibliome/." @default.
- W2292054199 created "2016-06-24" @default.
- W2292054199 creator A5009829929 @default.
- W2292054199 creator A5013216759 @default.
- W2292054199 creator A5014335552 @default.
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- W2292054199 creator A5051097609 @default.
- W2292054199 creator A5055332747 @default.
- W2292054199 creator A5087457643 @default.
- W2292054199 date "2016-09-01" @default.
- W2292054199 modified "2023-09-30" @default.
- W2292054199 title "Quantitative feature extraction from the Chinese hamster ovary bioprocess bibliome using a novel meta-analysis workflow" @default.
- W2292054199 cites W1154767 @default.
- W2292054199 cites W1544923801 @default.
- W2292054199 cites W1836448445 @default.
- W2292054199 cites W1966382501 @default.
- W2292054199 cites W1966422462 @default.
- W2292054199 cites W1977823630 @default.
- W2292054199 cites W1983426564 @default.
- W2292054199 cites W1983650071 @default.
- W2292054199 cites W1986020423 @default.
- W2292054199 cites W1988750241 @default.
- W2292054199 cites W1993465190 @default.
- W2292054199 cites W1993697685 @default.
- W2292054199 cites W1998051089 @default.
- W2292054199 cites W2000065954 @default.
- W2292054199 cites W2007341879 @default.
- W2292054199 cites W2008097801 @default.
- W2292054199 cites W2008907048 @default.
- W2292054199 cites W2010904098 @default.
- W2292054199 cites W2014022340 @default.
- W2292054199 cites W2014538668 @default.
- W2292054199 cites W2015352525 @default.
- W2292054199 cites W2015915283 @default.
- W2292054199 cites W2016211113 @default.
- W2292054199 cites W2018570286 @default.
- W2292054199 cites W2020561965 @default.
- W2292054199 cites W2023178000 @default.
- W2292054199 cites W2025794088 @default.
- W2292054199 cites W2026058196 @default.
- W2292054199 cites W2026074056 @default.
- W2292054199 cites W2026584088 @default.
- W2292054199 cites W2027986157 @default.
- W2292054199 cites W2033363721 @default.
- W2292054199 cites W2035827092 @default.
- W2292054199 cites W2038514608 @default.
- W2292054199 cites W2039293586 @default.
- W2292054199 cites W2041188132 @default.
- W2292054199 cites W2041282815 @default.
- W2292054199 cites W2042660863 @default.
- W2292054199 cites W2043410156 @default.
- W2292054199 cites W2044920551 @default.
- W2292054199 cites W2046378711 @default.
- W2292054199 cites W2047511535 @default.
- W2292054199 cites W2048430744 @default.
- W2292054199 cites W2054553530 @default.
- W2292054199 cites W2062537218 @default.
- W2292054199 cites W2064690707 @default.
- W2292054199 cites W2070434289 @default.
- W2292054199 cites W2073503722 @default.
- W2292054199 cites W2074876020 @default.
- W2292054199 cites W2079385933 @default.
- W2292054199 cites W2079933818 @default.
- W2292054199 cites W2082317883 @default.
- W2292054199 cites W2083233483 @default.
- W2292054199 cites W2083749028 @default.
- W2292054199 cites W2084060634 @default.
- W2292054199 cites W2085099920 @default.
- W2292054199 cites W2091300510 @default.
- W2292054199 cites W2092015535 @default.
- W2292054199 cites W2093775751 @default.
- W2292054199 cites W2096731906 @default.
- W2292054199 cites W2102232272 @default.
- W2292054199 cites W2102799896 @default.
- W2292054199 cites W2103839146 @default.
- W2292054199 cites W2105253399 @default.
- W2292054199 cites W2108587916 @default.
- W2292054199 cites W2109606373 @default.
- W2292054199 cites W2110279489 @default.
- W2292054199 cites W2110675735 @default.
- W2292054199 cites W2113777491 @default.
- W2292054199 cites W2114297659 @default.
- W2292054199 cites W2117763379 @default.
- W2292054199 cites W2121074166 @default.
- W2292054199 cites W2127971600 @default.
- W2292054199 cites W2134398178 @default.
- W2292054199 cites W2134412852 @default.
- W2292054199 cites W2134796222 @default.
- W2292054199 cites W2136819399 @default.
- W2292054199 cites W2142309981 @default.
- W2292054199 cites W2142963315 @default.
- W2292054199 cites W2148650601 @default.
- W2292054199 cites W2151722718 @default.
- W2292054199 cites W2154466433 @default.
- W2292054199 cites W2154882802 @default.
- W2292054199 cites W2161463357 @default.
- W2292054199 cites W2168072557 @default.
- W2292054199 cites W2169710531 @default.