Matches in SemOpenAlex for { <https://semopenalex.org/work/W2292066473> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2292066473 abstract "Zebrafish (Danio rerio) is an emerging model organism for pharmacological studies, tissue engineering, and genetically modified cardiomyocytes. However, early-staged cardiac function in zebrafish has not been well understood. We proposed to monitor electrocardiography (ECG) in zebrafish at embryonic and larva stage. Larvae were sedated with 0.01% tricane methanesulfonate and placed in E3 medium (5 mM NaCl, 0.17 mM KCl, 0.4 mM CaCl2, and 0.16 mM MgSO4) under microscope. A 5μm micropipette filled with 300% Danieau solution were in direct contact with the larva heart for voltage signal recording, and a second micropipette electrode was connected to the ground. Signal processing and wavelet transform enhanced the signal-to-noise ratios. ECG signals displaying distinct P wave and QRS complex were acquired from 7 days post-fertilization (dpf) to 42 dpf. Larva ECG patterns started to transform to the adult features at 35 dpf. When the larvae were treated with Amiodarone (1μM), a Class III anti-arrhythmic potassium channel blocker, single-peak QRS complex degenerated into multiple-peak and wide QRS duration. Thus, we provide a unique in vivo zebrafish model to assess developmental-staged cardiac conduction phenotype with implication for high throughput research. Research supported by NHLB 083015 and NHLBI 068689." @default.
- W2292066473 created "2016-06-24" @default.
- W2292066473 creator A5003369068 @default.
- W2292066473 creator A5045456651 @default.
- W2292066473 creator A5050097883 @default.
- W2292066473 creator A5081322672 @default.
- W2292066473 date "2010-04-01" @default.
- W2292066473 modified "2023-10-18" @default.
- W2292066473 title "Early‐staged electro‐cardiac conduction in larvae and embryonic zebrafish" @default.
- W2292066473 doi "https://doi.org/10.1096/fasebj.24.1_supplement.781.2" @default.
- W2292066473 hasPublicationYear "2010" @default.
- W2292066473 type Work @default.
- W2292066473 sameAs 2292066473 @default.
- W2292066473 citedByCount "0" @default.
- W2292066473 crossrefType "journal-article" @default.
- W2292066473 hasAuthorship W2292066473A5003369068 @default.
- W2292066473 hasAuthorship W2292066473A5045456651 @default.
- W2292066473 hasAuthorship W2292066473A5050097883 @default.
- W2292066473 hasAuthorship W2292066473A5081322672 @default.
- W2292066473 hasConcept C104317684 @default.
- W2292066473 hasConcept C105702510 @default.
- W2292066473 hasConcept C111773187 @default.
- W2292066473 hasConcept C126322002 @default.
- W2292066473 hasConcept C136229726 @default.
- W2292066473 hasConcept C145103041 @default.
- W2292066473 hasConcept C164705383 @default.
- W2292066473 hasConcept C185592680 @default.
- W2292066473 hasConcept C2776878037 @default.
- W2292066473 hasConcept C2777837822 @default.
- W2292066473 hasConcept C2780384893 @default.
- W2292066473 hasConcept C55493867 @default.
- W2292066473 hasConcept C71924100 @default.
- W2292066473 hasConcept C86803240 @default.
- W2292066473 hasConceptScore W2292066473C104317684 @default.
- W2292066473 hasConceptScore W2292066473C105702510 @default.
- W2292066473 hasConceptScore W2292066473C111773187 @default.
- W2292066473 hasConceptScore W2292066473C126322002 @default.
- W2292066473 hasConceptScore W2292066473C136229726 @default.
- W2292066473 hasConceptScore W2292066473C145103041 @default.
- W2292066473 hasConceptScore W2292066473C164705383 @default.
- W2292066473 hasConceptScore W2292066473C185592680 @default.
- W2292066473 hasConceptScore W2292066473C2776878037 @default.
- W2292066473 hasConceptScore W2292066473C2777837822 @default.
- W2292066473 hasConceptScore W2292066473C2780384893 @default.
- W2292066473 hasConceptScore W2292066473C55493867 @default.
- W2292066473 hasConceptScore W2292066473C71924100 @default.
- W2292066473 hasConceptScore W2292066473C86803240 @default.
- W2292066473 hasFunder F4320337338 @default.
- W2292066473 hasIssue "S1" @default.
- W2292066473 hasLocation W22920664731 @default.
- W2292066473 hasOpenAccess W2292066473 @default.
- W2292066473 hasPrimaryLocation W22920664731 @default.
- W2292066473 hasRelatedWork W1970583286 @default.
- W2292066473 hasRelatedWork W1981708334 @default.
- W2292066473 hasRelatedWork W2065730799 @default.
- W2292066473 hasRelatedWork W2076597447 @default.
- W2292066473 hasRelatedWork W2111039767 @default.
- W2292066473 hasRelatedWork W2279494018 @default.
- W2292066473 hasRelatedWork W2542527607 @default.
- W2292066473 hasRelatedWork W2807293741 @default.
- W2292066473 hasRelatedWork W345951196 @default.
- W2292066473 hasRelatedWork W4308039002 @default.
- W2292066473 hasVolume "24" @default.
- W2292066473 isParatext "false" @default.
- W2292066473 isRetracted "false" @default.
- W2292066473 magId "2292066473" @default.
- W2292066473 workType "article" @default.