FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2292071331> ?p ?o ?g. }

• W2292071331 abstract "Background: Responsiveness to Cetuximab alone can be mediated by an increase of Epidermal Growth factor Receptor (EGFR) Gene Copy Number (GCN). Aim of this study was to assess the role of EGFR-GCN in advanced colorectal cancer (CRC) patients receiving chemotherapy plus Cetuximab. Methods: One hundred and one advanced CRC patients (43 untreated- and 58 pre-treated) were retrospectively studied by fluorescence in situ hybridization (FISH) to assess EGFR-GCN and by immunohistochemistry (IHC) to determine EGFR expression. Sixty-one out of 101 patients were evaluated also for k-ras status by direct sequencing. Clinical end-points were response rate (RR), progression-free survival (PFS) and overall survival (OS). Results: Increased EGFR-GCN was found in 60/101 (59%) tumor samples. There was no correlation between intensity of EGFR-IHC and EGFR-GCN (p = 0.43). Patients receiving chemotherapy plus Cetuximab as first line treatment had a RR of 70% (30/43) while it was 18% (10/56) in the group with previous lines of therapy (p < 0.0001). RR was observed in 29/ 60 (48%) of patients with increased EGFR-GCN and in 6/28 (21%) in those without (p = 0.02). At multivariate analyses, number of chemotherapy lines and increased EGFR-GCN were predictive of response; EGFR-IHC score, increased EGFRGCN and number of chemotherapy lines were significantly associated with a significant better PFS. Response to therapy was the only prognostic predictive factor for OS. In the 60 patients analyzed for k-ras mutations, number of chemotherapy lines, increased EGFR-GCN and k-ras wild type status predicted a better PFS. Conclusion: In metastatic CRC patients treated with chemotherapy plus Cetuximab number of chemotherapy lines and increased EGFR-GCN were significantly associated with a better clinical outcome, independent of k-ras status." @default.
• W2292071331 created "2016-06-24" @default.
• W2292071331 creator A5008835803 @default.
• W2292071331 creator A5010507443 @default.
• W2292071331 creator A5022654643 @default.
• W2292071331 creator A5023710153 @default.
• W2292071331 creator A5040571142 @default.
• W2292071331 creator A5041578264 @default.
• W2292071331 creator A5048783483 @default.
• W2292071331 creator A5052556729 @default.
• W2292071331 creator A5055661232 @default.
• W2292071331 creator A5060428508 @default.
• W2292071331 creator A5061640360 @default.
• W2292071331 creator A5068721926 @default.
• W2292071331 creator A5076673353 @default.
• W2292071331 date "2010-01-01" @default.
• W2292071331 modified "2023-09-27" @default.
• W2292071331 title "number in 101 advanced colorectal cancer patients treated with chemotherapy plus cetuximab" @default.
• W2292071331 cites W1550092936 @default.
• W2292071331 cites W1580788756 @default.
• W2292071331 cites W1964071325 @default.
• W2292071331 cites W1979300931 @default.
• W2292071331 cites W1988043768 @default.
• W2292071331 cites W2025538303 @default.
• W2292071331 cites W2026401330 @default.
• W2292071331 cites W2048996882 @default.
• W2292071331 cites W2057443563 @default.
• W2292071331 cites W2095201384 @default.
• W2292071331 cites W2102897408 @default.
• W2292071331 cites W2106983577 @default.
• W2292071331 cites W2120490763 @default.
• W2292071331 cites W2122885616 @default.
• W2292071331 cites W2127238742 @default.
• W2292071331 cites W2139119404 @default.
• W2292071331 cites W2139248078 @default.
• W2292071331 cites W2142564546 @default.
• W2292071331 cites W2155311724 @default.
• W2292071331 cites W2156700619 @default.
• W2292071331 cites W2158475201 @default.
• W2292071331 cites W2260882811 @default.
• W2292071331 cites W2288085092 @default.
• W2292071331 cites W2613777440 @default.
• W2292071331 cites W3162309149 @default.
• W2292071331 cites W63726329 @default.
• W2292071331 cites W6982722 @default.
• W2292071331 cites W2115790682 @default.
• W2292071331 hasPublicationYear "2010" @default.
• W2292071331 type Work @default.
• W2292071331 sameAs 2292071331 @default.
• W2292071331 citedByCount "0" @default.
• W2292071331 crossrefType "journal-article" @default.
• W2292071331 hasAuthorship W2292071331A5008835803 @default.
• W2292071331 hasAuthorship W2292071331A5010507443 @default.
• W2292071331 hasAuthorship W2292071331A5022654643 @default.
• W2292071331 hasAuthorship W2292071331A5023710153 @default.
• W2292071331 hasAuthorship W2292071331A5040571142 @default.
• W2292071331 hasAuthorship W2292071331A5041578264 @default.
• W2292071331 hasAuthorship W2292071331A5048783483 @default.
• W2292071331 hasAuthorship W2292071331A5052556729 @default.
• W2292071331 hasAuthorship W2292071331A5055661232 @default.
• W2292071331 hasAuthorship W2292071331A5060428508 @default.
• W2292071331 hasAuthorship W2292071331A5061640360 @default.
• W2292071331 hasAuthorship W2292071331A5068721926 @default.
• W2292071331 hasAuthorship W2292071331A5076673353 @default.
• W2292071331 hasConcept C104317684 @default.
• W2292071331 hasConcept C121608353 @default.
• W2292071331 hasConcept C126322002 @default.
• W2292071331 hasConcept C143998085 @default.
• W2292071331 hasConcept C204232928 @default.
• W2292071331 hasConcept C2776694085 @default.
• W2292071331 hasConcept C2777542201 @default.
• W2292071331 hasConcept C2779438470 @default.
• W2292071331 hasConcept C2779998722 @default.
• W2292071331 hasConcept C2780521871 @default.
• W2292071331 hasConcept C2780739268 @default.
• W2292071331 hasConcept C30481170 @default.
• W2292071331 hasConcept C526805850 @default.
• W2292071331 hasConcept C55493867 @default.
• W2292071331 hasConcept C71924100 @default.
• W2292071331 hasConcept C86803240 @default.
• W2292071331 hasConceptScore W2292071331C104317684 @default.
• W2292071331 hasConceptScore W2292071331C121608353 @default.
• W2292071331 hasConceptScore W2292071331C126322002 @default.
• W2292071331 hasConceptScore W2292071331C143998085 @default.
• W2292071331 hasConceptScore W2292071331C204232928 @default.
• W2292071331 hasConceptScore W2292071331C2776694085 @default.
• W2292071331 hasConceptScore W2292071331C2777542201 @default.
• W2292071331 hasConceptScore W2292071331C2779438470 @default.
• W2292071331 hasConceptScore W2292071331C2779998722 @default.
• W2292071331 hasConceptScore W2292071331C2780521871 @default.
• W2292071331 hasConceptScore W2292071331C2780739268 @default.
• W2292071331 hasConceptScore W2292071331C30481170 @default.
• W2292071331 hasConceptScore W2292071331C526805850 @default.
• W2292071331 hasConceptScore W2292071331C55493867 @default.
• W2292071331 hasConceptScore W2292071331C71924100 @default.
• W2292071331 hasConceptScore W2292071331C86803240 @default.
• W2292071331 hasLocation W22920713311 @default.
• W2292071331 hasOpenAccess W2292071331 @default.
• W2292071331 hasPrimaryLocation W22920713311 @default.
• W2292071331 hasRelatedWork W1452766815 @default.

• next