Matches in SemOpenAlex for { <https://semopenalex.org/work/W2292073126> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2292073126 endingPage "723" @default.
- W2292073126 startingPage "719" @default.
- W2292073126 abstract "Clp protease is a high relative molecular mass, ATP-dependent protease found in the cytoplasm of Escherichia coli. Clp protease is composed of two protein components, Clp A, which has ATPase activity, and Clp P, which has the proteolytic active site and is activated by Clp A in the presence of ATP. Clp P subunits (Mr = 21,500) are arranged in two hexagonal rings directly superimposed on each other, and under low salt conditions two dodecamers associate to form a particle with Mr approximately 440,000. Clp A (subunit Mr = 83,000) and Clp P do not associate in the absence of nucleotide, but Clp A with ATP bound associates with Clp P to form an active proteolytic complex with Mr approximately 700,000. Although adenosine 5'-[beta gamma-imido]triphosphate (AMPPNP) weakly promotes association between Clp A and Clp P, non-hydrolysable analogues of ATP do not activate proteolysis, indicating that association between the components is not sufficient to allow proteolysis. Association between Clp A and Clp P does not alter the basal ATPase activity of Clp A, but addition of protein substrates is accompanied by an increase in ATP hydrolysis by Clp A. Chemically-inactivated Clp P or inactive mutants of Clp P also associate with Clp A, but no increase in the ATPase activity of Clp A is observed, either in the presence or absence of protein substrates, when Clp P is inactive. Thus the increased ATP hydrolysis is dependent on active proteolysis.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2292073126 created "2016-06-24" @default.
- W2292073126 creator A5087235422 @default.
- W2292073126 date "1991-08-01" @default.
- W2292073126 modified "2023-09-26" @default.
- W2292073126 title "ATP-promoted interaction between Clp A and Clp P in activation of Clp protease from <i>Escherichia coli</i>" @default.
- W2292073126 doi "https://doi.org/10.1042/bst0190719" @default.
- W2292073126 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1783205" @default.
- W2292073126 hasPublicationYear "1991" @default.
- W2292073126 type Work @default.
- W2292073126 sameAs 2292073126 @default.
- W2292073126 citedByCount "52" @default.
- W2292073126 countsByYear W22920731262012 @default.
- W2292073126 countsByYear W22920731262013 @default.
- W2292073126 countsByYear W22920731262014 @default.
- W2292073126 countsByYear W22920731262015 @default.
- W2292073126 countsByYear W22920731262018 @default.
- W2292073126 countsByYear W22920731262019 @default.
- W2292073126 countsByYear W22920731262020 @default.
- W2292073126 countsByYear W22920731262022 @default.
- W2292073126 crossrefType "journal-article" @default.
- W2292073126 hasAuthorship W2292073126A5087235422 @default.
- W2292073126 hasConcept C101635128 @default.
- W2292073126 hasConcept C104292427 @default.
- W2292073126 hasConcept C104317684 @default.
- W2292073126 hasConcept C141315368 @default.
- W2292073126 hasConcept C143065580 @default.
- W2292073126 hasConcept C153911025 @default.
- W2292073126 hasConcept C181199279 @default.
- W2292073126 hasConcept C185592680 @default.
- W2292073126 hasConcept C190062978 @default.
- W2292073126 hasConcept C23265538 @default.
- W2292073126 hasConcept C2776714187 @default.
- W2292073126 hasConcept C2779564974 @default.
- W2292073126 hasConcept C2781307694 @default.
- W2292073126 hasConcept C547475151 @default.
- W2292073126 hasConcept C55493867 @default.
- W2292073126 hasConcept C86803240 @default.
- W2292073126 hasConceptScore W2292073126C101635128 @default.
- W2292073126 hasConceptScore W2292073126C104292427 @default.
- W2292073126 hasConceptScore W2292073126C104317684 @default.
- W2292073126 hasConceptScore W2292073126C141315368 @default.
- W2292073126 hasConceptScore W2292073126C143065580 @default.
- W2292073126 hasConceptScore W2292073126C153911025 @default.
- W2292073126 hasConceptScore W2292073126C181199279 @default.
- W2292073126 hasConceptScore W2292073126C185592680 @default.
- W2292073126 hasConceptScore W2292073126C190062978 @default.
- W2292073126 hasConceptScore W2292073126C23265538 @default.
- W2292073126 hasConceptScore W2292073126C2776714187 @default.
- W2292073126 hasConceptScore W2292073126C2779564974 @default.
- W2292073126 hasConceptScore W2292073126C2781307694 @default.
- W2292073126 hasConceptScore W2292073126C547475151 @default.
- W2292073126 hasConceptScore W2292073126C55493867 @default.
- W2292073126 hasConceptScore W2292073126C86803240 @default.
- W2292073126 hasIssue "3" @default.
- W2292073126 hasLocation W22920731261 @default.
- W2292073126 hasLocation W22920731262 @default.
- W2292073126 hasOpenAccess W2292073126 @default.
- W2292073126 hasPrimaryLocation W22920731261 @default.
- W2292073126 hasRelatedWork W1490397999 @default.
- W2292073126 hasRelatedWork W1997453949 @default.
- W2292073126 hasRelatedWork W2001383742 @default.
- W2292073126 hasRelatedWork W2055544854 @default.
- W2292073126 hasRelatedWork W2094828672 @default.
- W2292073126 hasRelatedWork W2132513295 @default.
- W2292073126 hasRelatedWork W2292073126 @default.
- W2292073126 hasRelatedWork W2416266357 @default.
- W2292073126 hasRelatedWork W2793719545 @default.
- W2292073126 hasRelatedWork W3016409291 @default.
- W2292073126 hasVolume "19" @default.
- W2292073126 isParatext "false" @default.
- W2292073126 isRetracted "false" @default.
- W2292073126 magId "2292073126" @default.
- W2292073126 workType "article" @default.