Matches in SemOpenAlex for { <https://semopenalex.org/work/W2292156201> ?p ?o ?g. }
- W2292156201 abstract "C. elegans embryonic elongation is a morphogenetic event driven by actomyosin contractility and muscle-induced tension transmitted through hemidesmosomes. A role for the microtubule cytoskeleton has also been proposed, but its contribution remains poorly characterized. Here, we investigate the organization of the non-centrosomal microtubule arrays present in the epidermis and assess their function in elongation. We show that the microtubule regulators γ-tubulin and NOCA-1 are recruited to hemidesmosomes and adherens junctions early in elongation. Several parallel approaches suggest that microtubule nucleation occurs from these sites. Disrupting the epidermal microtubule array by overexpressing the microtubule-severing protein Spastin or by inhibiting the C. elegans ninein homolog NOCA-1 in the epidermis mildly affected elongation. However, microtubules were essential for elongation when hemidesmosomes or the activity of the Rho-kinase LET-502/ROCK were partially compromised. Imaging of junctional components and genetic analyses suggest that epidermal microtubules function together with Rho-kinase to promote the transport of E-cadherin to adherens junctions and myotactin to hemidesmosomes. Our results indicate that LET-502/ROCK role in junctional remodeling is likely independent of its established function as a myosin II activator, but requires a microtubule-dependent pathway involving the syntaxin SYX-5. Hence, we propose that non-centrosomal microtubules organized by epidermal junctions contribute to elongation by transporting junction remodeling factors, rather than having a mechanical role." @default.
- W2292156201 created "2016-06-24" @default.
- W2292156201 creator A5005133486 @default.
- W2292156201 creator A5006132193 @default.
- W2292156201 creator A5012177307 @default.
- W2292156201 creator A5017437915 @default.
- W2292156201 creator A5030538355 @default.
- W2292156201 creator A5043043816 @default.
- W2292156201 creator A5060356943 @default.
- W2292156201 creator A5074572864 @default.
- W2292156201 creator A5089810278 @default.
- W2292156201 creator A5091189717 @default.
- W2292156201 date "2015-01-01" @default.
- W2292156201 modified "2023-10-09" @default.
- W2292156201 title "Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to promote <i>C. elegans</i> elongation" @default.
- W2292156201 cites W118771962 @default.
- W2292156201 cites W1481817740 @default.
- W2292156201 cites W1542565045 @default.
- W2292156201 cites W1603627149 @default.
- W2292156201 cites W1764705044 @default.
- W2292156201 cites W1935003487 @default.
- W2292156201 cites W1944127002 @default.
- W2292156201 cites W1963574778 @default.
- W2292156201 cites W1975753731 @default.
- W2292156201 cites W1977549705 @default.
- W2292156201 cites W1978533535 @default.
- W2292156201 cites W1979366429 @default.
- W2292156201 cites W1980908755 @default.
- W2292156201 cites W1985501881 @default.
- W2292156201 cites W1988308292 @default.
- W2292156201 cites W1989952069 @default.
- W2292156201 cites W1990157435 @default.
- W2292156201 cites W1990221937 @default.
- W2292156201 cites W1990507118 @default.
- W2292156201 cites W1997975124 @default.
- W2292156201 cites W2004002282 @default.
- W2292156201 cites W2004714825 @default.
- W2292156201 cites W2015468345 @default.
- W2292156201 cites W2016692139 @default.
- W2292156201 cites W2017522546 @default.
- W2292156201 cites W2025607087 @default.
- W2292156201 cites W2033932577 @default.
- W2292156201 cites W2034406261 @default.
- W2292156201 cites W2034935332 @default.
- W2292156201 cites W2036870980 @default.
- W2292156201 cites W2038492783 @default.
- W2292156201 cites W2040667056 @default.
- W2292156201 cites W2042019193 @default.
- W2292156201 cites W2046861581 @default.
- W2292156201 cites W2048961736 @default.
- W2292156201 cites W2050154120 @default.
- W2292156201 cites W2052190647 @default.
- W2292156201 cites W2055644846 @default.
- W2292156201 cites W2060297895 @default.
- W2292156201 cites W2060328732 @default.
- W2292156201 cites W2063053541 @default.
- W2292156201 cites W2068215757 @default.
- W2292156201 cites W2075802731 @default.
- W2292156201 cites W2078683492 @default.
- W2292156201 cites W2079458003 @default.
- W2292156201 cites W2080207847 @default.
- W2292156201 cites W2084334125 @default.
- W2292156201 cites W2086061027 @default.
- W2292156201 cites W2089008488 @default.
- W2292156201 cites W2090150346 @default.
- W2292156201 cites W2093032008 @default.
- W2292156201 cites W2095612044 @default.
- W2292156201 cites W2101216488 @default.
- W2292156201 cites W2102905759 @default.
- W2292156201 cites W2105713350 @default.
- W2292156201 cites W2112973000 @default.
- W2292156201 cites W2113799806 @default.
- W2292156201 cites W2114526467 @default.
- W2292156201 cites W2115803302 @default.
- W2292156201 cites W2118647189 @default.
- W2292156201 cites W2121404998 @default.
- W2292156201 cites W2121533701 @default.
- W2292156201 cites W2122235477 @default.
- W2292156201 cites W2122684024 @default.
- W2292156201 cites W2129018625 @default.
- W2292156201 cites W2137974614 @default.
- W2292156201 cites W2141415210 @default.
- W2292156201 cites W2144859098 @default.
- W2292156201 cites W2144967153 @default.
- W2292156201 cites W2152456282 @default.
- W2292156201 cites W2156419662 @default.
- W2292156201 cites W2157319245 @default.
- W2292156201 cites W2166774112 @default.
- W2292156201 cites W2167960449 @default.
- W2292156201 cites W2168451433 @default.
- W2292156201 cites W2169621308 @default.
- W2292156201 cites W2170621952 @default.
- W2292156201 cites W2171845995 @default.
- W2292156201 cites W2204776416 @default.
- W2292156201 cites W2323916105 @default.
- W2292156201 cites W2410106639 @default.
- W2292156201 cites W4232690806 @default.
- W2292156201 doi "https://doi.org/10.1242/dev.126615" @default.
- W2292156201 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6514414" @default.
- W2292156201 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26586219" @default.