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- W2292157466 abstract "Oxidative stress and chronic low-grade inflammation in the lungs are associated with aging and may contribute to age-related immune dysfunction. To maintain lung homeostasis, chronic inflammation is countered by enhanced expression of proresolving/antiinflammatory factors. Here, we show that age-dependent increases of one such factor in the lungs, a phospholipase A2 (PLA2) group IID (PLA2G2D) with antiinflammatory properties, contributed to worse outcomes in mice infected with severe acute respiratory syndrome-coronavirus (SARS-CoV). Strikingly, infection of mice lacking PLA2G2D expression (Pla2g2d(-/-) mice) converted a uniformly lethal infection to a nonlethal one (>80% survival), subsequent to development of enhanced respiratory DC migration to the draining lymph nodes, augmented antivirus T cell responses, and diminished lung damage. We also observed similar effects in influenza A virus-infected middle-aged Pla2g2d(-/-) mice. Furthermore, oxidative stress, probably via lipid peroxidation, was found to induce PLA2G2D expression in mice and in human monocyte-derived macrophages. Thus, our results suggest that directed inhibition of a single inducible phospholipase, PLA2G2D, in the lungs of older patients with severe respiratory infections is potentially an attractive therapeutic intervention to restore immune function." @default.
- W2292157466 created "2016-06-24" @default.
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- W2292157466 date "2015-09-21" @default.
- W2292157466 modified "2023-10-13" @default.
- W2292157466 title "Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome–CoV infection" @default.
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- W2292157466 cites W1981336118 @default.
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- W2292157466 cites W1990049863 @default.
- W2292157466 cites W1990580642 @default.
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- W2292157466 cites W2139891708 @default.
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- W2292157466 cites W2149667429 @default.
- W2292157466 cites W2150158737 @default.
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- W2292157466 doi "https://doi.org/10.1084/jem.20150632" @default.
- W2292157466 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4612096" @default.
- W2292157466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26392224" @default.
- W2292157466 hasPublicationYear "2015" @default.
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