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• W2292180855 endingPage "8861" @default.
• W2292180855 startingPage "8848" @default.
• W2292180855 abstract "FoxO1 binds to insulin response elements located in the promoters of insulin-like growth factor-binding protein 1 (IGFBP1) and glucose-6-phosphatase (G6Pase), activating their expression. Insulin-mediated phosphorylation of FoxO1 promotes cytoplasmic translocation, inhibiting FoxO1-mediated transactivation. We have previously demonstrated that FoxO1 opens and remodels chromatin assembled from the IGFBP1 promoter via a highly conserved winged helix motif. This finding, which established FoxO1 as a factor, suggested a model whereby FoxO1 chromatin remodeling at regulatory targets facilitates binding and recruitment of additional regulatory factors. However, the impact of FoxO1 phosphorylation on its ability to bind chromatin and the effect of FoxO1 loss on recruitment of neighboring transcription factors at its regulatory targets in liver chromatin is unknown. In this study, we demonstrate that an amino acid substitution that mimics insulin-mediated phosphorylation of a serine in the winged helix DNA binding motif curtails FoxO1 nucleosome binding. We also demonstrate that shRNA-mediated loss of FoxO1 binding to the IGFBP1 and G6Pase promoters in HepG2 cells significantly reduces binding of RNA polymerase II and the pioneer factors FoxA1/A2. Knockdown of FoxA1 similarly reduced binding of RNA polymerase II and FoxO1. Reduction in acetylation of histone H3 Lys-27 accompanies loss of FoxO1 and FoxA1/A2 binding. Interdependent binding of FoxO1 and FoxA1/A2 possibly entails cooperative binding because FoxO1 and FoxA1/A2 facilitate one another's binding to IGFPB1 promoter DNA. These results illustrate how transcription factors can nucleate transcriptional events in chromatin in response to signaling events and suggest a model for regulation of hepatic glucose metabolism through interdependent FoxO/FoxA binding." @default.
• W2292180855 created "2016-06-24" @default.
• W2292180855 creator A5006442777 @default.
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• W2292180855 creator A5063843267 @default.
• W2292180855 creator A5072798746 @default.
• W2292180855 creator A5075733831 @default.
• W2292180855 date "2016-04-01" @default.
• W2292180855 modified "2023-10-17" @default.
• W2292180855 title "Loss of Interdependent Binding by the FoxO1 and FoxA1/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin-sensitive Genes" @default.
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• W2292180855 doi "https://doi.org/10.1074/jbc.m115.677583" @default.
• W2292180855 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4861452" @default.
• W2292180855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26929406" @default.
• W2292180855 hasPublicationYear "2016" @default.
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