Matches in SemOpenAlex for { <https://semopenalex.org/work/W2292181957> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2292181957 abstract "Background It was suggested that K+ channels family identified as two-pore potassium channels (K2P) function as leak K+ efflux that regulates membrane potential complementary to Ca2+, ATP and voltage dependent K+ channels. Does opening of K2P channels dilate vascular beds, or do they tune membrane potential only? Methods and results Patch-clamp technique was used to record an ATP-γs elicited delayed K+-current in freshly dissociated myocytes. This current was not inhibited by a cocktail of K+ channels blockers (TEA, 4AP, charibdotoxin, apamin, glibenclamide). Tested purinergic agonists (ATP, UTP) – except for ADP - activated delayed K+-current indicating that at least P2Y11 receptor stimulates delayed K+-current. 12,13-didecanoate also stimulated this current. ATPγs-elicited K+-current amplitude decreased in staurosporine and G6850 pretreated cells. Acid pH (7 and 6) inhibited when basic pH (8) stimulated amplitude of ATPγs-elicited K+-current. ATP-γs produced a vasodilation in endothelium-denuded thoracic aorta rings contracted by the K+-channels blockers and pre-treated by carbenoxolone. Vasodilation was inhibited by acid pH (6). Conclusions Our results demonstrate that ATP-γs dilates pre-stretched thoracic aorta rings via stimulation of pH sensitive K+-current through P2Y receptors. Taken together our data provide new cellular mechanism of vasoregulation via K2P-like channels." @default.
- W2292181957 created "2016-06-24" @default.
- W2292181957 creator A5023833342 @default.
- W2292181957 creator A5029685342 @default.
- W2292181957 creator A5043635502 @default.
- W2292181957 creator A5061657758 @default.
- W2292181957 creator A5066492925 @default.
- W2292181957 creator A5066604159 @default.
- W2292181957 date "2010-04-01" @default.
- W2292181957 modified "2023-10-12" @default.
- W2292181957 title "K2P‐like current in freshly dissociated mouse thoracic aorta: the impact on thoracic aorta diameter" @default.
- W2292181957 doi "https://doi.org/10.1096/fasebj.24.1_supplement.985.2" @default.
- W2292181957 hasPublicationYear "2010" @default.
- W2292181957 type Work @default.
- W2292181957 sameAs 2292181957 @default.
- W2292181957 citedByCount "0" @default.
- W2292181957 crossrefType "journal-article" @default.
- W2292181957 hasAuthorship W2292181957A5023833342 @default.
- W2292181957 hasAuthorship W2292181957A5029685342 @default.
- W2292181957 hasAuthorship W2292181957A5043635502 @default.
- W2292181957 hasAuthorship W2292181957A5061657758 @default.
- W2292181957 hasAuthorship W2292181957A5066492925 @default.
- W2292181957 hasAuthorship W2292181957A5066604159 @default.
- W2292181957 hasConcept C120770815 @default.
- W2292181957 hasConcept C12554922 @default.
- W2292181957 hasConcept C126322002 @default.
- W2292181957 hasConcept C134018914 @default.
- W2292181957 hasConcept C147944092 @default.
- W2292181957 hasConcept C160225129 @default.
- W2292181957 hasConcept C170493617 @default.
- W2292181957 hasConcept C178790620 @default.
- W2292181957 hasConcept C181911157 @default.
- W2292181957 hasConcept C185592680 @default.
- W2292181957 hasConcept C2776864027 @default.
- W2292181957 hasConcept C2776919887 @default.
- W2292181957 hasConcept C2778815084 @default.
- W2292181957 hasConcept C2779768347 @default.
- W2292181957 hasConcept C2779980429 @default.
- W2292181957 hasConcept C2780921233 @default.
- W2292181957 hasConcept C2781295685 @default.
- W2292181957 hasConcept C517785266 @default.
- W2292181957 hasConcept C55493867 @default.
- W2292181957 hasConcept C555293320 @default.
- W2292181957 hasConcept C57306754 @default.
- W2292181957 hasConcept C71924100 @default.
- W2292181957 hasConcept C83743174 @default.
- W2292181957 hasConcept C86803240 @default.
- W2292181957 hasConceptScore W2292181957C120770815 @default.
- W2292181957 hasConceptScore W2292181957C12554922 @default.
- W2292181957 hasConceptScore W2292181957C126322002 @default.
- W2292181957 hasConceptScore W2292181957C134018914 @default.
- W2292181957 hasConceptScore W2292181957C147944092 @default.
- W2292181957 hasConceptScore W2292181957C160225129 @default.
- W2292181957 hasConceptScore W2292181957C170493617 @default.
- W2292181957 hasConceptScore W2292181957C178790620 @default.
- W2292181957 hasConceptScore W2292181957C181911157 @default.
- W2292181957 hasConceptScore W2292181957C185592680 @default.
- W2292181957 hasConceptScore W2292181957C2776864027 @default.
- W2292181957 hasConceptScore W2292181957C2776919887 @default.
- W2292181957 hasConceptScore W2292181957C2778815084 @default.
- W2292181957 hasConceptScore W2292181957C2779768347 @default.
- W2292181957 hasConceptScore W2292181957C2779980429 @default.
- W2292181957 hasConceptScore W2292181957C2780921233 @default.
- W2292181957 hasConceptScore W2292181957C2781295685 @default.
- W2292181957 hasConceptScore W2292181957C517785266 @default.
- W2292181957 hasConceptScore W2292181957C55493867 @default.
- W2292181957 hasConceptScore W2292181957C555293320 @default.
- W2292181957 hasConceptScore W2292181957C57306754 @default.
- W2292181957 hasConceptScore W2292181957C71924100 @default.
- W2292181957 hasConceptScore W2292181957C83743174 @default.
- W2292181957 hasConceptScore W2292181957C86803240 @default.
- W2292181957 hasIssue "S1" @default.
- W2292181957 hasLocation W22921819571 @default.
- W2292181957 hasOpenAccess W2292181957 @default.
- W2292181957 hasPrimaryLocation W22921819571 @default.
- W2292181957 hasRelatedWork W126676278 @default.
- W2292181957 hasRelatedWork W1698820125 @default.
- W2292181957 hasRelatedWork W1986802101 @default.
- W2292181957 hasRelatedWork W1987046469 @default.
- W2292181957 hasRelatedWork W1997807240 @default.
- W2292181957 hasRelatedWork W2004104295 @default.
- W2292181957 hasRelatedWork W2011357302 @default.
- W2292181957 hasRelatedWork W2080413816 @default.
- W2292181957 hasRelatedWork W2292181957 @default.
- W2292181957 hasRelatedWork W4205809030 @default.
- W2292181957 hasVolume "24" @default.
- W2292181957 isParatext "false" @default.
- W2292181957 isRetracted "false" @default.
- W2292181957 magId "2292181957" @default.
- W2292181957 workType "article" @default.