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• W2292248942 abstract "// Marine Baptissart 1, 2, 3, 4, * , Emmanuelle Martinot 1, 2, 3, 4, * , Aurélie Vega 1, 2, 3, 4 , Lauriane Sédes 1, 2, 3, 4 , Betty Rouaisnel 1, 2, 3, 4 , Angélique de Haze 1, 2, 3, 4 , Silvère Baron 1, 2, 3, 4 , Kristina Schoonjans 5 , Françoise Caira 1, 2, 3, 4 , David H. Volle 1, 2, 3, 4 1 INSERM U 1103, Laboratoire GReD, Campus Universitaire des Cézeaux, TSA 60026, CS 60026, 63178 Aubière Cedex, France 2 Université Clermont Auvergne, Université Blaise Pascal, GReD, F-63178 Aubière, France 3 CNRS, UMR 6293, GReD, F-63178 Aubière, France 4 Centre de Recherche en Nutrition Humaine d’Auvergne, F-63000 Clermont-Ferrand, France 5 Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland * These authors have contributed equally to this work Correspondence to: David H. Volle, e-mail: david.volle@inserm.fr Keywords: testicular steroidogenesis, nuclear receptors, hypothalamo-pituitary axis, bile acid, germ cell apoptosis Received: June 03, 2015     Accepted: January 22, 2016     Published: February 03, 2016 ABSTRACT The bile acid receptor Farnesol-X-Receptor alpha (FRXα) is a member of the nuclear receptor superfamily. FRXα is expressed in the interstitial compartment of the adult testes, which contain the Leydig cells. In adult, short term treatment (12 hours) with FRXα agonist inhibits the expression of steroidogenic genes via the induction of the Small heterodimer partner (SHP). However the consequences of FRXα activation on testicular pathophysiology have never been evaluated. We demonstrate here that mice fed a diet supplemented with bile acid during pubertal age show increased incidence of infertility. This is associated with altered differentiation and increase apoptosis of germ cells due to lower testosterone levels. At the molecular level, next to the repression of basal steroidogenesis via the induction expression of Shp and Dax-1 , two repressors of steroidogenesis, the main action of the BA-FRXα signaling is through lowering the Leydig cell sensitivity to the hypothalamo-pituitary axis, the main regulator of testicular endocrine function. In conclusion, BA-FRXα signaling is a critical actor during sexual maturation." @default.
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• W2292248942 date "2016-02-03" @default.
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• W2292248942 title "Bile acid-FXRα pathways regulate male sexual maturation in mice" @default.
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• W2292248942 doi "https://doi.org/10.18632/oncotarget.7153" @default.
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