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• W2292257778 abstract "Circulating tumor DNA (ct DNA ) is an emerging field of cancer research. For lung cancer, non‐invasive genotyping of EGFR is the foremost application. The activating mutations represent the ct DNA from all cancer cells, and the T790M‐resistant mutation represents that from resistant cells. We examined the ct DNA dynamics of EGFR mutations by using deep sequencing with a massively parallel DNA sequencer. We obtained 190 plasma samples from 57 patients at various times during the treatment course and classified them according to treatment status. The mutation detection rate of exon 19 deletion/L858R in plasma was high at the initiation of treatment with epidermal growth factor receptor tyrosine kinase inhibitor ( EGFR ‐ TKI ; P = 0.001), suppressed during EGFR ‐ TKI treatment before disease progression, and elevated after the onset of disease progression ( P = 0.023). The mutation detection rate of T790M was low until the onset of disease progression and elevated thereafter ( P = 0.01). Samples across the development of disease progression were obtained from 10 patients and showed a correlation between increased ct DNA level and disease progression. Decreased ct DNA level in response to the initiation of EGFR ‐ TKI was observed in 4 of 6 eligible patients. In two patients, the ct DNA dynamics suggested the presence of cancer cell populations only with the T790M mutation. In another patient, the T790M ct DNA represented cell subpopulations that respond to cytotoxic agents differently from the major population. Considering the high incidence, ct DNA could be a clinical parameter to complement information from image analyses." @default.
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• W2292257778 date "2016-02-18" @default.
• W2292257778 modified "2023-10-04" @default.
• W2292257778 title "Dynamics of circulating tumor <scp>DNA</scp> represented by the activating and resistant mutations in epidermal growth factor receptor tyrosine kinase inhibitor treatment" @default.
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• W2292257778 doi "https://doi.org/10.1111/cas.12860" @default.
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