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- W2292290374 abstract "All highly proliferating cells have two absolute requirements: abundant sources of energy and building blocks such as proteins, carbohydrates, and lipids. Specific gene products that coordinate massive induction of both energy and these chemical products are essential for normal organismal development and when constitutively activated would be anticipated to elicit uncontrolled growth or cancer. MYC is candidate gene product that can coordinate the transcription of genes that regulate energy and intermediary metabolism through its canonical targets through specific and more general mechanisms of gene binding, induction, and suppression [1, 2, 3]. Previous reports have noted MYC's role in the regulation of glucose and glutamine pathways to drive energy production. Further, MYC regulates nearly all of the central metabolic pathways in the cells, such as glycolysis, glutaminolysis, and nucleotide biosynthesis [1, 2, 3]." @default.
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- W2292290374 date "2016-02-06" @default.
- W2292290374 modified "2023-10-18" @default.
- W2292290374 title "Metabolic vulnerabilities of MYC-induced cancer" @default.
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- W2292290374 doi "https://doi.org/10.18632/oncotarget.7223" @default.
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