FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2292382619> ?p ?o ?g. }

• W2292382619 endingPage "10458" @default.
• W2292382619 startingPage "10448" @default.
• W2292382619 abstract "Obesity and related metabolic abnormalities play a key role in liver carcinogenesis. Non-alcoholic steatohepatitis (NASH), which is often complicated with obesity and diabetes mellitus, is associated with the development of hepatocellular carcinoma (HCC). Sodium alginate (SA), which is extracted from brown seaweeds, is marketed as a weight loss supplement because of its high viscosity and gelling properties. In the present study, we examined the effects of SA on the progression of NASH and related liver carcinogenesis in monosodium glutamate (MSG)-treated mice, which show obesity, diabetes mellitus, and NASH-like histopathological changes. Male MSG-mice were intraperitoneally injected with diethylnitrosamine at 2 weeks of age, and, thereafter, they received a basal diet containing high- or low-molecular-weight SA throughout the experiment (16 weeks). At sacrifice, control MSG-treated mice fed the basal-diet showed significant obesity, hyperinsulinemia, steatosis and hepatic tumor development. SA administration suppressed body weight gain; improved insulin sensitivity, hyperinsulinemia, and hyperleptinemia; attenuated inflammation in the liver and white adipose tissue; and inhibited hepatic lipogenesis and progression of NASH. SA also reduced oxidative stress and increased anti-oxidant enzyme levels in the liver. Development of hepatic tumors, including liver cell adenoma and HCC, and hepatic pre-neoplastic lesions was significantly inhibited by SA supplementation. In conclusion, oral SA supplementation improves liver steatosis, insulin resistance, chronic inflammation, and oxidative stress, preventing the development of liver tumorigenesis in obese and diabetic mice. SA may have ability to suppress steatosis-related liver carcinogenesis in obese and diabetic subjects." @default.
• W2292382619 created "2016-06-24" @default.
• W2292382619 creator A5005286789 @default.
• W2292382619 creator A5009724017 @default.
• W2292382619 creator A5036864018 @default.
• W2292382619 creator A5041284607 @default.
• W2292382619 creator A5041437307 @default.
• W2292382619 creator A5063439535 @default.
• W2292382619 creator A5065822023 @default.
• W2292382619 creator A5084247658 @default.
• W2292382619 creator A5085073972 @default.
• W2292382619 date "2016-02-08" @default.
• W2292382619 modified "2023-10-14" @default.
• W2292382619 title "Sodium alginate prevents progression of non-alcoholic steatohepatitis and liver carcinogenesis in obese and diabetic mice" @default.
• W2292382619 cites W1590059630 @default.
• W2292382619 cites W1805877675 @default.
• W2292382619 cites W1942197918 @default.
• W2292382619 cites W1968872717 @default.
• W2292382619 cites W1974439644 @default.
• W2292382619 cites W1978723895 @default.
• W2292382619 cites W1987582842 @default.
• W2292382619 cites W1995501999 @default.
• W2292382619 cites W1998677519 @default.
• W2292382619 cites W2008869160 @default.
• W2292382619 cites W2011599861 @default.
• W2292382619 cites W2016103822 @default.
• W2292382619 cites W2022271344 @default.
• W2292382619 cites W2026365179 @default.
• W2292382619 cites W2030374593 @default.
• W2292382619 cites W2040267509 @default.
• W2292382619 cites W2047092958 @default.
• W2292382619 cites W2061662539 @default.
• W2292382619 cites W2062812115 @default.
• W2292382619 cites W2067740038 @default.
• W2292382619 cites W2075187391 @default.
• W2292382619 cites W2076633494 @default.
• W2292382619 cites W2076683498 @default.
• W2292382619 cites W2080998956 @default.
• W2292382619 cites W2095205890 @default.
• W2292382619 cites W2098533879 @default.
• W2292382619 cites W2106121337 @default.
• W2292382619 cites W2109132597 @default.
• W2292382619 cites W2113751056 @default.
• W2292382619 cites W2114199165 @default.
• W2292382619 cites W2116619784 @default.
• W2292382619 cites W2120213924 @default.
• W2292382619 cites W2136024338 @default.
• W2292382619 cites W2136483056 @default.
• W2292382619 cites W2136795008 @default.
• W2292382619 cites W2137052325 @default.
• W2292382619 cites W2144032315 @default.
• W2292382619 cites W2145861991 @default.
• W2292382619 cites W2147125377 @default.
• W2292382619 cites W2150883486 @default.
• W2292382619 cites W2155849969 @default.
• W2292382619 cites W2155868778 @default.
• W2292382619 cites W2157727415 @default.
• W2292382619 cites W2165202791 @default.
• W2292382619 cites W2171753559 @default.
• W2292382619 cites W2171857016 @default.
• W2292382619 cites W2340234859 @default.
• W2292382619 cites W2409246534 @default.
• W2292382619 cites W4238497443 @default.
• W2292382619 cites W4249727000 @default.
• W2292382619 cites W85969758 @default.
• W2292382619 doi "https://doi.org/10.18632/oncotarget.7249" @default.
• W2292382619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4891131" @default.
• W2292382619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26871288" @default.
• W2292382619 hasPublicationYear "2016" @default.
• W2292382619 type Work @default.
• W2292382619 sameAs 2292382619 @default.
• W2292382619 citedByCount "21" @default.
• W2292382619 countsByYear W22923826192017 @default.
• W2292382619 countsByYear W22923826192019 @default.
• W2292382619 countsByYear W22923826192020 @default.
• W2292382619 countsByYear W22923826192021 @default.
• W2292382619 countsByYear W22923826192022 @default.
• W2292382619 countsByYear W22923826192023 @default.
• W2292382619 crossrefType "journal-article" @default.
• W2292382619 hasAuthorship W2292382619A5005286789 @default.
• W2292382619 hasAuthorship W2292382619A5009724017 @default.
• W2292382619 hasAuthorship W2292382619A5036864018 @default.
• W2292382619 hasAuthorship W2292382619A5041284607 @default.
• W2292382619 hasAuthorship W2292382619A5041437307 @default.
• W2292382619 hasAuthorship W2292382619A5063439535 @default.
• W2292382619 hasAuthorship W2292382619A5065822023 @default.
• W2292382619 hasAuthorship W2292382619A5084247658 @default.
• W2292382619 hasAuthorship W2292382619A5085073972 @default.
• W2292382619 hasBestOaLocation W22923826191 @default.
• W2292382619 hasConcept C126322002 @default.
• W2292382619 hasConcept C134018914 @default.
• W2292382619 hasConcept C141359234 @default.
• W2292382619 hasConcept C171089720 @default.
• W2292382619 hasConcept C2776175330 @default.
• W2292382619 hasConcept C2777391703 @default.
• W2292382619 hasConcept C2778772119 @default.
• W2292382619 hasConcept C2779134260 @default.
• W2292382619 hasConcept C2779478299 @default.

• next