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• W2292566285 startingPage "269" @default.
• W2292566285 abstract "The bioassay-guided fractionation of the aril of Myristica fragrans (mace spice) yielded five phenolic compounds, one new acyclic bis phenylpropanoid (1) and four previously known phenolic compounds: compounds (1) (S) 1-(3,4,5-trimethoxyphenyl)-2-(3-methoxy-5-(prop-1-yl) phenyl)-propan-1-ol, (2) benzenemethanol; α-[1-[2,6-dimethoxy-4-(2-propen-1-yl)phenoxy]ethyl]-3,4-dimethoxy-1-acetate, (3) odoratisol A, phenol, 4-[(2S,3S)-2,3-dihydro-7-methoxy-3-methyl-5-(1E)-1-propenyl-2-benzofuranyl]-2,6-dimethoxy, (4) 1,3-benzodioxate-5-methanol,α-[1-[2,6-dimethoxy-4-(2-propenyl)phenoxy]ethyl]-acetate, (5) licarin C; benzofuran,2,3-dihydro-7-methoxy-3-methyl-5-(1E)-1-yl-2-(3,4,5-trimethoxyphenyl). An NMR tube Mosher ester reaction was used in an approach to characterize and determine the assignment of the absolute configuration of the new isolated chiral alcohol (1). The PARP-1 inhibitory activity was evaluated for compound (1) (IC50 = 3.04 μM), compound (2) (IC50 = 0.001 μM), compound (4) (IC50 = 22.07 μM) and compound (5) (IC50 = 3.11 μM). Furthermore, the isolated secondary metabolites were tested for NF-κB and K-Ras inhibitory activities. When tested in the p65 assay, compounds (2) and (4) displayed potent NF-κB inhibition (IC50 = 1.5 nM and 3.4 nM, respectively)." @default.
• W2292566285 created "2016-06-24" @default.
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• W2292566285 date "2016-07-01" @default.
• W2292566285 modified "2023-10-15" @default.
• W2292566285 title "New acyclic bis phenylpropanoid and neolignans, from Myristica fragrans Houtt., exhibiting PARP-1 and NF-κB inhibitory effects" @default.
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• W2292566285 doi "https://doi.org/10.1016/j.foodchem.2016.01.060" @default.
• W2292566285 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4770456" @default.
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